Endothelial cell-cell adhesion and signaling

Camilla Cerutti; Anne Ridley

doi:10.1016/j.yexcr.2017.06.003

Endothelial cell-cell adhesion and signaling

Camilla Cerutti, Anne Ridley

Research output: Contribution to journal › Article › peer-review

173 Citations (Scopus)

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Abstract

Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.

Original language	English
Journal	Experimental Cell Research
Early online date	8 Jun 2017
DOIs	https://doi.org/10.1016/j.yexcr.2017.06.003
Publication status	E-pub ahead of print - 8 Jun 2017

Keywords

endothelial cells
adherens junctions
tight junctions
Rho
GTPases
Rap GTPases
actin cytoskeleton
cell signalling

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10.1016/j.yexcr.2017.06.003

Endothelial cell-cell adhesion_CERUTTI_Published online 8 June 2017_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 1.6 MBLicence: CC BY-NC-ND

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title = "Endothelial cell-cell adhesion and signaling",

abstract = "Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.",

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T1 - Endothelial cell-cell adhesion and signaling

AU - Cerutti, Camilla

AU - Ridley, Anne

PY - 2017/6/8

Y1 - 2017/6/8

N2 - Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.

AB - Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.

KW - endothelial cells

KW - adherens junctions

KW - tight junctions

KW - Rho

KW - GTPases

KW - Rap GTPases

KW - actin cytoskeleton

KW - cell signalling

U2 - 10.1016/j.yexcr.2017.06.003

DO - 10.1016/j.yexcr.2017.06.003

M3 - Article

SN - 0014-4827

JO - Experimental Cell Research

JF - Experimental Cell Research

ER -

Endothelial cell-cell adhesion and signaling

Abstract

Keywords

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