Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice

Jithu V James, Joe Varghese, Andrew T Mckie, Sophie Vaulont, Molly Jacob*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract


Original languageEnglish
Pages (from-to)118621
JournalBiochimica et biophysica acta-Molecular cell research
Volume1867
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • AMP-Activated Protein Kinases/metabolism
  • Animals
  • Cells, Cultured
  • Ferritins/metabolism
  • Glucose/metabolism
  • Glucose-6-Phosphatase/metabolism
  • Hepatocytes/cytology
  • Hepcidins/deficiency
  • Insulin/metabolism
  • Iron/metabolism
  • Iron Chelating Agents/pharmacology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oxidative Stress/drug effects
  • Phosphorylation/drug effects
  • Proto-Oncogene Proteins c-akt/metabolism
  • Receptors, Transferrin/genetics
  • Signal Transduction/drug effects

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