TY - CHAP
T1 - Environmental pressures on transgenerational epigenetic inheritance
T2 - An evolutionary development mechanism influencing atypical neurodevelopment in autism?
AU - Adhya, Dwaipayan
AU - Massrali, Aicha
AU - Paul, Arkoprovo
AU - Kotter, Mark
AU - Carroll, Jason
AU - Srivastava, Deepak
AU - Price, Jack
AU - Baron-Cohen, Simon
N1 - Publisher Copyright:
© Cambridge University Press 2020. All rights reserved.
PY - 2020/3/19
Y1 - 2020/3/19
N2 - Research in developmental neuropsychiatric conditions has revealed morphological and functional divergences in the brain. In some cases, the divergences occur due to one or two highly penetrant genomic mutations. In case such as autism, mutations in varied sets of genes may produce a convergent autism behavioral phenotype. It is thus likely that there may be other forms of non-genomic regulation of gene expression during development affecting behavioral outcome. Epigenetic gene regulation is one such mechanism that can permanently switch on or switch off gene expression, and these epigenetic changes can be inherited from one cell stage to another during differentiation, mimicking the effects of genomic mutations. Epigenetic gene regulation occurring during early developmental stages of cellular differentiation, which are highly sensitive to environmental cues, is the primary mechanism responsible for the phenomenon known as evolutionary development or "evo-devo." This chapter discusses these mechanisms in the context of autism and the environmental factors that influence it.
AB - Research in developmental neuropsychiatric conditions has revealed morphological and functional divergences in the brain. In some cases, the divergences occur due to one or two highly penetrant genomic mutations. In case such as autism, mutations in varied sets of genes may produce a convergent autism behavioral phenotype. It is thus likely that there may be other forms of non-genomic regulation of gene expression during development affecting behavioral outcome. Epigenetic gene regulation is one such mechanism that can permanently switch on or switch off gene expression, and these epigenetic changes can be inherited from one cell stage to another during differentiation, mimicking the effects of genomic mutations. Epigenetic gene regulation occurring during early developmental stages of cellular differentiation, which are highly sensitive to environmental cues, is the primary mechanism responsible for the phenomenon known as evolutionary development or "evo-devo." This chapter discusses these mechanisms in the context of autism and the environmental factors that influence it.
UR - http://www.scopus.com/inward/record.url?scp=85193635518&partnerID=8YFLogxK
U2 - 10.1017/9781108131797.010
DO - 10.1017/9781108131797.010
M3 - Chapter
AN - SCOPUS:85193635518
SN - 9781316642825
SP - 97
EP - 112
BT - The Cambridge Handbook of Evolutionary Perspectives on Human Behavior
PB - Cambridge University Press
ER -