Eosinophilic spongiosis in association with bullous pemphigoid and chronic lymphocytic leukaemia

TY - JOUR

T1 - Eosinophilic spongiosis in association with bullous pemphigoid and chronic lymphocytic leukaemia

AU - Ameen, M

AU - Pembroke, A C

AU - Black, M M

AU - Russell-Jones, R

PY - 2000

Y1 - 2000

N2 - We report the onset of an unusual blistering eruption following a diagnosis of B-cell chronic lymphocytic leukaemia (CLL). The histology consistently showed eosinophilic spongiosis, but the diagnosis of bullous pemphigoid was only confirmed after 13 years by repeated immunofluorescence studies. The occurrence of subepidermal blistering diseases in association with B-cell lymphoproliferative disorders is rare; a recent study showed that the majority of these cases are epidermolysis bullosa acquisita, confirmed by immunological studies. Only two cases of immunofluorescence-proven bullous pemphigoid in association with CLL have been previously reported.

AB - We report the onset of an unusual blistering eruption following a diagnosis of B-cell chronic lymphocytic leukaemia (CLL). The histology consistently showed eosinophilic spongiosis, but the diagnosis of bullous pemphigoid was only confirmed after 13 years by repeated immunofluorescence studies. The occurrence of subepidermal blistering diseases in association with B-cell lymphoproliferative disorders is rare; a recent study showed that the majority of these cases are epidermolysis bullosa acquisita, confirmed by immunological studies. Only two cases of immunofluorescence-proven bullous pemphigoid in association with CLL have been previously reported.

UR - http://www.scopus.com/inward/record.url?scp=0033846879&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2000.03674.x

DO - 10.1046/j.1365-2133.2000.03674.x

M3 - Article

SN - 1365-2133

VL - 143

SP - 421

EP - 424

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 2

ER -