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EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing

Research output: Contribution to journalArticle

A A Battaglia, K Sehayek, J Grist, S B McMahon, I Gavazzi

Original languageEnglish
Pages (from-to)339 - 340
Number of pages2
JournalNature Neuroscience
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2003

King's Authors

Abstract

Eph receptor tyrosine kinases and their ephrin ligands are involved in crucial aspects of nervous system circuit assembly during development1, 2, but their functional roles in the mature nervous system are poorly understood. We investigated their role in pain processing, using a combination of immunohistochemical, behavioral, biochemical and primary cell culture techniques. Here we report an in vivo role for EphB−ephrinB interactions as modulators of synaptic efficacy in the spinal cord, contributing to sensory abnormalities in persistent pain states.

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