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Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue

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Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. / Xavier, Guilherme Machado; Miletich, Isabelle; Cobourne, Martyn Timothy.

In: Frontiers in Physiology, Vol. 23, No. 7, 60, 23.02.2016.

Research output: Contribution to journalArticle

Harvard

Xavier, GM, Miletich, I & Cobourne, MT 2016, 'Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue', Frontiers in Physiology, vol. 23, no. 7, 60. https://doi.org/10.3389/fphys.2016.00060

APA

Xavier, G. M., Miletich, I., & Cobourne, M. T. (2016). Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Frontiers in Physiology, 23(7), [60]. https://doi.org/10.3389/fphys.2016.00060

Vancouver

Xavier GM, Miletich I, Cobourne MT. Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Frontiers in Physiology. 2016 Feb 23;23(7). 60. https://doi.org/10.3389/fphys.2016.00060

Author

Xavier, Guilherme Machado ; Miletich, Isabelle ; Cobourne, Martyn Timothy. / Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. In: Frontiers in Physiology. 2016 ; Vol. 23, No. 7.

Bibtex Download

@article{6c104fc93c9744dba6cc2ce6b005cf6b,
title = "Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue",
abstract = "The Eph family receptor-interacting (ephrin) ligands and erythropoietin-producing hepatocellular carcinoma (Eph) receptors constitute the largest known family of receptor tyrosine kinases. Ephrin ligands and their receptors form an important cell communication system with widespread roles in normal physiology and disease pathogenesis. In order to investigate potential roles of the ephrin-Eph system during palatogenesis and tongue development, we have characterized the cellular mRNA expression of family members EphrinA1-A3, EphA1-A8, and EphrinB2, EphB1, EphB4 during murine embryogenesis between embryonic day 13.5-16.5 using radioactive in situ hybridization. With the exception of EphA6 and ephrinA3, all genes were regionally expressed during the process of palatogenesis, with restricted and often overlapping domains. Transcripts were identified in the palate epithelium, localized at the tip of the palatal shelves, in the mesenchyme and also confined to the medial epithelium seam. Numerous Eph transcripts were also identified during tongue development. In particular, EphA1 and EphA2 demonstrated a highly restricted and specific expression in the tongue epithelium at all stages examined, whereas EphA3 was strongly expressed in the lateral tongue mesenchyme. These results suggest regulatory roles for ephrin-EphA signaling in development of the murine palate and tongue.",
keywords = "palatogenesis, tongue development, ephrin, Eph, in situ hybridization, gene expression",
author = "Xavier, {Guilherme Machado} and Isabelle Miletich and Cobourne, {Martyn Timothy}",
year = "2016",
month = "2",
day = "23",
doi = "10.3389/fphys.2016.00060",
language = "English",
volume = "23",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers",
number = "7",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue

AU - Xavier, Guilherme Machado

AU - Miletich, Isabelle

AU - Cobourne, Martyn Timothy

PY - 2016/2/23

Y1 - 2016/2/23

N2 - The Eph family receptor-interacting (ephrin) ligands and erythropoietin-producing hepatocellular carcinoma (Eph) receptors constitute the largest known family of receptor tyrosine kinases. Ephrin ligands and their receptors form an important cell communication system with widespread roles in normal physiology and disease pathogenesis. In order to investigate potential roles of the ephrin-Eph system during palatogenesis and tongue development, we have characterized the cellular mRNA expression of family members EphrinA1-A3, EphA1-A8, and EphrinB2, EphB1, EphB4 during murine embryogenesis between embryonic day 13.5-16.5 using radioactive in situ hybridization. With the exception of EphA6 and ephrinA3, all genes were regionally expressed during the process of palatogenesis, with restricted and often overlapping domains. Transcripts were identified in the palate epithelium, localized at the tip of the palatal shelves, in the mesenchyme and also confined to the medial epithelium seam. Numerous Eph transcripts were also identified during tongue development. In particular, EphA1 and EphA2 demonstrated a highly restricted and specific expression in the tongue epithelium at all stages examined, whereas EphA3 was strongly expressed in the lateral tongue mesenchyme. These results suggest regulatory roles for ephrin-EphA signaling in development of the murine palate and tongue.

AB - The Eph family receptor-interacting (ephrin) ligands and erythropoietin-producing hepatocellular carcinoma (Eph) receptors constitute the largest known family of receptor tyrosine kinases. Ephrin ligands and their receptors form an important cell communication system with widespread roles in normal physiology and disease pathogenesis. In order to investigate potential roles of the ephrin-Eph system during palatogenesis and tongue development, we have characterized the cellular mRNA expression of family members EphrinA1-A3, EphA1-A8, and EphrinB2, EphB1, EphB4 during murine embryogenesis between embryonic day 13.5-16.5 using radioactive in situ hybridization. With the exception of EphA6 and ephrinA3, all genes were regionally expressed during the process of palatogenesis, with restricted and often overlapping domains. Transcripts were identified in the palate epithelium, localized at the tip of the palatal shelves, in the mesenchyme and also confined to the medial epithelium seam. Numerous Eph transcripts were also identified during tongue development. In particular, EphA1 and EphA2 demonstrated a highly restricted and specific expression in the tongue epithelium at all stages examined, whereas EphA3 was strongly expressed in the lateral tongue mesenchyme. These results suggest regulatory roles for ephrin-EphA signaling in development of the murine palate and tongue.

KW - palatogenesis

KW - tongue development

KW - ephrin

KW - Eph

KW - in situ hybridization

KW - gene expression

U2 - 10.3389/fphys.2016.00060

DO - 10.3389/fphys.2016.00060

M3 - Article

VL - 23

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - 7

M1 - 60

ER -

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