King's College London

Research portal

Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England

Research output: Contribution to journalArticle

Standard

Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England. / Ladhani, Shamez N.; Flood, Jessica S.; Amirthalingam, Gayatri; Mieli-Vergani, Giorgina; Bansal, Sanjay; Davison, Suzanne; Naik, Sandhia; Riordan, Andrew; Shingadia, Delane; Tudor-Williams, Gareth; Sira, Jaswant; Kelly, Deirdre A.; Ramsay, Mary E.; ChicB.

In: Pediatric Infectious Disease Journal, Vol. 33, No. 2, 02.2014, p. 130-135.

Research output: Contribution to journalArticle

Harvard

Ladhani, SN, Flood, JS, Amirthalingam, G, Mieli-Vergani, G, Bansal, S, Davison, S, Naik, S, Riordan, A, Shingadia, D, Tudor-Williams, G, Sira, J, Kelly, DA, Ramsay, ME & ChicB 2014, 'Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England' Pediatric Infectious Disease Journal, vol 33, no. 2, pp. 130-135. DOI: 10.1097/INF.0000000000000196

APA

Ladhani, S. N., Flood, J. S., Amirthalingam, G., Mieli-Vergani, G., Bansal, S., Davison, S., ... ChicB (2014). Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England. Pediatric Infectious Disease Journal, 33(2), 130-135. DOI: 10.1097/INF.0000000000000196

Vancouver

Ladhani SN, Flood JS, Amirthalingam G, Mieli-Vergani G, Bansal S, Davison S et al. Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England. Pediatric Infectious Disease Journal. 2014 Feb;33(2):130-135. Available from, DOI: 10.1097/INF.0000000000000196

Author

Ladhani, Shamez N.; Flood, Jessica S.; Amirthalingam, Gayatri; Mieli-Vergani, Giorgina; Bansal, Sanjay; Davison, Suzanne; Naik, Sandhia; Riordan, Andrew; Shingadia, Delane; Tudor-Williams, Gareth; Sira, Jaswant; Kelly, Deirdre A.; Ramsay, Mary E.; ChicB / Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England.

In: Pediatric Infectious Disease Journal, Vol. 33, No. 2, 02.2014, p. 130-135.

Research output: Contribution to journalArticle

Bibtex Download

@article{62461ae252b1440fababfbfc668d9cc2,
title = "Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England",
keywords = "chronic hepatitis B, children, transmission, prevalence, epidemiology, VIRUS INFECTION, HIGH-RISK, TRANSMISSION, VACCINATION, CHILDREN, PREVENTION, BACTEREMIA, BABIES, WALES",
author = "Ladhani, {Shamez N.} and Flood, {Jessica S.} and Gayatri Amirthalingam and Giorgina Mieli-Vergani and Sanjay Bansal and Suzanne Davison and Sandhia Naik and Andrew Riordan and Delane Shingadia and Gareth Tudor-Williams and Jaswant Sira and Kelly, {Deirdre A.} and Ramsay, {Mary E.} and ChicB",
year = "2014",
month = "2",
doi = "10.1097/INF.0000000000000196",
volume = "33",
pages = "130--135",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Epidemiology and Clinical Features of Childhood Chronic Hepatitis B Infection Diagnosed in England

AU - Ladhani,Shamez N.

AU - Flood,Jessica S.

AU - Amirthalingam,Gayatri

AU - Mieli-Vergani,Giorgina

AU - Bansal,Sanjay

AU - Davison,Suzanne

AU - Naik,Sandhia

AU - Riordan,Andrew

AU - Shingadia,Delane

AU - Tudor-Williams,Gareth

AU - Sira,Jaswant

AU - Kelly,Deirdre A.

AU - Ramsay,Mary E.

AU - ChicB

PY - 2014/2

Y1 - 2014/2

N2 - <p>Background: This study aimed to estimate the prevalence of childhood chronic hepatitis B (CHB) infection diagnosed in England using capture-recapture analysis of 2 independent data sources and to describe the clinical and epidemiological characteristics, management, complications and outcome of children with CHB.</p><p>Methods: Pediatric specialists were contacted to report all CHB cases in children aged </p><p>Results: Capture-recapture analysis estimated 448 diagnosed CHB cases (prevalence, 4.6/100,000) in England, of whom only 44% had been referred for specialist follow up. Clinical information for 325 cases under specialist care revealed that half the cases (n = 164, 50%) had been born overseas, mainly Sub-Saharan Africa and Eastern Europe, whereas half the UK-born children were either Pakistani (25%) or Chinese (25%). Most children (n = 216, 66%) were asymptomatic, with only 60 (18.5%) ever receiving any antiviral therapy, although 2 developed cirrhosis in childhood and 1 hepatocellular carcinoma. Horizontal transmission among UK-born children was identified in only 3 children born since 2001, when universal antenatal hepatitis B virus screening was introduced. Most children born to antenatally diagnosed hepatitis B virus-positive mothers (49/51, 96%) had received at least 1 hepatitis B vaccine dose after birth.</p><p>Conclusions: In England, the prevalence of diagnosed childhood CHB is low, although the potential number of undiagnosed cases is difficult to estimate. Further efforts are required to strengthen the current antenatal screening program and newly diagnosed cases should be referred for specialist follow up.</p>

AB - <p>Background: This study aimed to estimate the prevalence of childhood chronic hepatitis B (CHB) infection diagnosed in England using capture-recapture analysis of 2 independent data sources and to describe the clinical and epidemiological characteristics, management, complications and outcome of children with CHB.</p><p>Methods: Pediatric specialists were contacted to report all CHB cases in children aged </p><p>Results: Capture-recapture analysis estimated 448 diagnosed CHB cases (prevalence, 4.6/100,000) in England, of whom only 44% had been referred for specialist follow up. Clinical information for 325 cases under specialist care revealed that half the cases (n = 164, 50%) had been born overseas, mainly Sub-Saharan Africa and Eastern Europe, whereas half the UK-born children were either Pakistani (25%) or Chinese (25%). Most children (n = 216, 66%) were asymptomatic, with only 60 (18.5%) ever receiving any antiviral therapy, although 2 developed cirrhosis in childhood and 1 hepatocellular carcinoma. Horizontal transmission among UK-born children was identified in only 3 children born since 2001, when universal antenatal hepatitis B virus screening was introduced. Most children born to antenatally diagnosed hepatitis B virus-positive mothers (49/51, 96%) had received at least 1 hepatitis B vaccine dose after birth.</p><p>Conclusions: In England, the prevalence of diagnosed childhood CHB is low, although the potential number of undiagnosed cases is difficult to estimate. Further efforts are required to strengthen the current antenatal screening program and newly diagnosed cases should be referred for specialist follow up.</p>

KW - chronic hepatitis B

KW - children

KW - transmission

KW - prevalence

KW - epidemiology

KW - VIRUS INFECTION

KW - HIGH-RISK

KW - TRANSMISSION

KW - VACCINATION

KW - CHILDREN

KW - PREVENTION

KW - BACTEREMIA

KW - BABIES

KW - WALES

U2 - 10.1097/INF.0000000000000196

DO - 10.1097/INF.0000000000000196

M3 - Article

VL - 33

SP - 130

EP - 135

JO - Pediatric Infectious Disease Journal

T2 - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 2

ER -

View graph of relations

© 2015 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454