Epidemiology of chronic inflammatory neuropathies in southeast England

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Abstract

Background and purpose: There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN). Methods: Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast England population of 3 557 352 people. Results: The crude prevalences were as follows: CIDP, 2.84 (95% CI 2.31-3.45); MMN, 0.53 (95% CI 0.32-0.83); and PDN, 1.04 (95% CI 0.73-1.43) per 100 000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70-79 years) and PDN (70-79 years) than in those with MMN (50-59 years). Disability was greater in CIDP and PDN, with median (range) overall neuropathy limitations scores of 4 (0-8) and 4 (1-6), respectively, than in MMN, with a score of 2 (1-5). Conclusion: The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalEuropean journal of neurology : the official journal of the European Federation of Neurological Societies
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • Disability
  • Epidemiology
  • Multifocal motor neuropathy
  • Paraproteinaemic demyelinating neuropathy

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