Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Nina Schmolka; Mélanie Wencker; Adrian C Hayday; Bruno Silva-Santos

doi:10.1016/j.smim.2015.01.001

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Nina Schmolka, Mélanie Wencker, Adrian C Hayday, Bruno Silva-Santos

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Seminars in Immunology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2015.01.001
Publication status	Published - Feb 2015

Keywords

Animals
Cell Differentiation
Epigenesis, Genetic
Humans
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocytes
Thymus Gland
Transcription, Genetic

Access to Document

10.1016/j.smim.2015.01.001

Cite this

@article{1abcdc6ac798471c892f18d00c8feed4,

title = "Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space",

abstract = "γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels.",

keywords = "Animals, Cell Differentiation, Epigenesis, Genetic, Humans, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocytes, Thymus Gland, Transcription, Genetic",

author = "Nina Schmolka and M{\'e}lanie Wencker and Hayday, {Adrian C} and Bruno Silva-Santos",

year = "2015",

month = feb,

doi = "10.1016/j.smim.2015.01.001",

language = "English",

volume = "27",

pages = "19--25",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "ACADEMIC PRESS INC",

number = "1",

}

TY - JOUR

T1 - Epigenetic and transcriptional regulation of γδ T cell differentiation

T2 - Programming cells for responses in time and space

AU - Schmolka, Nina

AU - Wencker, Mélanie

AU - Hayday, Adrian C

AU - Silva-Santos, Bruno

PY - 2015/2

Y1 - 2015/2

N2 - γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels.

AB - γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels.

KW - Animals

KW - Cell Differentiation

KW - Epigenesis, Genetic

KW - Humans

KW - Receptors, Antigen, T-Cell, gamma-delta

KW - T-Lymphocytes

KW - Thymus Gland

KW - Transcription, Genetic

U2 - 10.1016/j.smim.2015.01.001

DO - 10.1016/j.smim.2015.01.001

M3 - Review article

C2 - 25726512

SN - 1044-5323

VL - 27

SP - 19

EP - 25

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 1

ER -

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Abstract

Keywords

Access to Document

Fingerprint

Cite this