Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells

Val Yianni, Paul T. Sharpe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.

Original languageEnglish
Article number115309
Publication statusPublished - May 2020


  • Epigenetics
  • Mesenchymal stem cells
  • Odontoblast
  • Osteoblast
  • Pericytes
  • Perivascular cells
  • RNAseq
  • Transcriptomics


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