King's College London

Research portal

Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells

Research output: Contribution to journalArticle

Original languageEnglish
Article number115309
JournalBone
Volume134
DOIs
Publication statusPublished - May 2020

King's Authors

Abstract

The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454