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Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells

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Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells. / Yianni, Val; Sharpe, Paul T.

In: Bone, Vol. 134, 115309, 05.2020.

Research output: Contribution to journalArticle

Harvard

Yianni, V & Sharpe, PT 2020, 'Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells', Bone, vol. 134, 115309. https://doi.org/10.1016/j.bone.2020.115309

APA

Yianni, V., & Sharpe, P. T. (2020). Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells. Bone, 134, [115309]. https://doi.org/10.1016/j.bone.2020.115309

Vancouver

Yianni V, Sharpe PT. Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells. Bone. 2020 May;134. 115309. https://doi.org/10.1016/j.bone.2020.115309

Author

Yianni, Val ; Sharpe, Paul T. / Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells. In: Bone. 2020 ; Vol. 134.

Bibtex Download

@article{1b09def285b74efd96f86c9f59a9d608,
title = "Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells",
abstract = "The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.",
keywords = "Epigenetics, Mesenchymal stem cells, Odontoblast, Osteoblast, Pericytes, Perivascular cells, RNAseq, Transcriptomics",
author = "Val Yianni and Sharpe, {Paul T.}",
year = "2020",
month = "5",
doi = "10.1016/j.bone.2020.115309",
language = "English",
volume = "134",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells

AU - Yianni, Val

AU - Sharpe, Paul T.

PY - 2020/5

Y1 - 2020/5

N2 - The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.

AB - The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.

KW - Epigenetics

KW - Mesenchymal stem cells

KW - Odontoblast

KW - Osteoblast

KW - Pericytes

KW - Perivascular cells

KW - RNAseq

KW - Transcriptomics

UR - http://www.scopus.com/inward/record.url?scp=85081936414&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2020.115309

DO - 10.1016/j.bone.2020.115309

M3 - Article

C2 - 32145460

AN - SCOPUS:85081936414

VL - 134

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 115309

ER -

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