Research output: Contribution to journal › Article › peer-review
Charlotte Tye, Fiona McEwen, Holan Liang, Emma Woodhouse, Lisa Underwood, Elizabeth Shephard, Edward Barker, Fintan Sheerin, Nicholas Higgins, Juul Steenbruggen, Patrick Bolton
Original language | English |
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Pages (from-to) | e30-e35 |
Journal | Epilepsia |
Volume | 64 |
Issue number | 3 |
Early online date | 12 Jan 2023 |
DOIs | |
Accepted/In press | 9 Jan 2023 |
E-pub ahead of print | 12 Jan 2023 |
Published | 2 Feb 2023 |
Additional links |
Epilepsy severity mediates association_TYE_2023_GOLD AAM
Tye_TS_2000_ADHD_Epilepsiia.pdf, 666 KB, application/pdf
Uploaded date:16 Jan 2023
Version:Accepted author manuscript
The association between attention-deficit/hyperactivity disorder (ADHD) and tuberous sclerosis complex (TSC) is widely reported, with support for the role of epilepsy, yet the mechanisms underlying the association across development are unclear. The Tuberous Sclerosis 2000 Study is a prospective longitudinal study of TSC. In Phase 1 of the study, baseline measures of epilepsy, cortical tuber load, and mutation were obtained with 125 children ages 0–16 years. In Phase 2, at an average of 8 years later, ADHD symptoms were measured for 81 of the participants. Structural equation modeling revealed an indirect pathway from genetic mutation, to cortical tuber load, to epileptic spasm severity in infancy, to ADHD symptoms in middle childhood and adolescence, in addition to a pathway linking current seizure severity to ADHD symptoms. Findings were retained when intelligence quotient (IQ) was entered as a correlated factor. The findings support a cascading developmental pathway to ADHD symptoms mediated by early-onset and severe epilepsy in the first 2 years of life. This warrants detailed investigation of seizure characteristics and cognitive and behavioral sequelae associated with ADHD from early in life, to further the understanding of the association between ADHD and early-onset epilepsy across syndromic and non-syndromic populations.
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