Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Rafael Di Marco Barros; Natalie A. Roberts; Robin J. Dart; Pierre Vantourout; Anett Jandke; Oliver Nussbaumer; Livija Deban; Sara Cipolat; Rosie Hart; Maria Iannitto; Adam Laing; Bradley Spencer-Dene; Philip East; Deena Gibbons; Peter M. Irving; Pablo Pereira; Ulrich Steinhoff; Adrian Hayday

doi:10.1016/j.cell.2016.08.030

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Rafael Di Marco Barros, Natalie A. Roberts, Robin J. Dart, Pierre Vantourout, Anett Jandke, Oliver Nussbaumer, Livija Deban, Sara Cipolat, Rosie Hart, Maria Iannitto, Adam Laing, Bradley Spencer-Dene, Philip East, Deena Gibbons, Peter M. Irving, Pablo Pereira, Ulrich Steinhoff, Adrian Hayday

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Abstract

Summary: Many body surfaces harbor organ-specific gd T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vg5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by thymic epithelial
cells and suprabasal keratinocytes. However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-Vg7+ gd compartment. Uninfluenced bymicrobial or food antigens, this activity evokes the developmental selection of TCRab+ repertoires. Indeed, Btnl1 and Btnl6 jointly induce TCR-dependent responses specifically in intestinal Vg7+ cells. Likewise, humangut epithelial cells express BTNL3 and BTNL8 that jointly induce selective TCR-dependent responses of human colonic Vg4+ cells. Hence, a conserved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell compartments.

Original language	English
Pages (from-to)	203-218.e17
Journal	Cell
Volume	167
Issue number	1
Early online date	15 Sept 2016
DOIs	https://doi.org/10.1016/j.cell.2016.08.030
Publication status	Published - 22 Sept 2016

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Epithelia Use Butyrophilin-like_Di Marco Barros_Accepted 16August2016 GOLD VoR CC BYFinal published version, 8.2 MBLicence: CC BY

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Di Marco Barros, R., Roberts, NA., Dart, RJ., Vantourout, P., Jandke, A., Nussbaumer, O., Deban, L., Cipolat, S., Hart, R., Iannitto, M., Laing, A., Spencer-Dene, B., East, P., Gibbons, D., Irving, PM., Pereira, P., Steinhoff, U., & Hayday, A. (2016). Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell, 167(1), 203-218.e17. https://doi.org/10.1016/j.cell.2016.08.030

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title = "Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments",

abstract = "Summary: Many body surfaces harbor organ-specific gd T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vg5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by thymic epithelialcells and suprabasal keratinocytes. However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-Vg7+ gd compartment. Uninfluenced bymicrobial or food antigens, this activity evokes the developmental selection of TCRab+ repertoires. Indeed, Btnl1 and Btnl6 jointly induce TCR-dependent responses specifically in intestinal Vg7+ cells. Likewise, humangut epithelial cells express BTNL3 and BTNL8 that jointly induce selective TCR-dependent responses of human colonic Vg4+ cells. Hence, a conserved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell compartments.",

author = "Rafael Di Marco Barros and Natalie A. Roberts and Robin J. Dart and Pierre Vantourout and Anett Jandke and Oliver Nussbaumer and Livija Deban and Sara Cipolat and Rosie Hart and Maria Iannitto and Adam Laing and Bradley Spencer-Dene and Philip East and Deena Gibbons and Peter M. Irving and Pablo Pereira and Ulrich Steinhoff and Adrian Hayday",

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Di Marco Barros, R, Roberts, NA, Dart, RJ, Vantourout, P , Jandke, A , Nussbaumer, O, Deban, L, Cipolat, S, Hart, R, Iannitto, M , Laing, A, Spencer-Dene, B, East, P, Gibbons, D, Irving, PM, Pereira, P, Steinhoff, U & Hayday, A 2016, 'Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments', Cell, vol. 167, no. 1, pp. 203-218.e17. https://doi.org/10.1016/j.cell.2016.08.030

TY - JOUR

T1 - Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

AU - Di Marco Barros, Rafael

AU - Roberts, Natalie A.

AU - Dart, Robin J.

AU - Vantourout, Pierre

AU - Jandke, Anett

AU - Nussbaumer, Oliver

AU - Deban, Livija

AU - Cipolat, Sara

AU - Hart, Rosie

AU - Iannitto, Maria

AU - Laing, Adam

AU - Spencer-Dene, Bradley

AU - East, Philip

AU - Gibbons, Deena

AU - Irving, Peter M.

AU - Pereira, Pablo

AU - Steinhoff, Ulrich

AU - Hayday, Adrian

PY - 2016/9/22

Y1 - 2016/9/22

N2 - Summary: Many body surfaces harbor organ-specific gd T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vg5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by thymic epithelialcells and suprabasal keratinocytes. However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-Vg7+ gd compartment. Uninfluenced bymicrobial or food antigens, this activity evokes the developmental selection of TCRab+ repertoires. Indeed, Btnl1 and Btnl6 jointly induce TCR-dependent responses specifically in intestinal Vg7+ cells. Likewise, humangut epithelial cells express BTNL3 and BTNL8 that jointly induce selective TCR-dependent responses of human colonic Vg4+ cells. Hence, a conserved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell compartments.

AB - Summary: Many body surfaces harbor organ-specific gd T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vg5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by thymic epithelialcells and suprabasal keratinocytes. However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-Vg7+ gd compartment. Uninfluenced bymicrobial or food antigens, this activity evokes the developmental selection of TCRab+ repertoires. Indeed, Btnl1 and Btnl6 jointly induce TCR-dependent responses specifically in intestinal Vg7+ cells. Likewise, humangut epithelial cells express BTNL3 and BTNL8 that jointly induce selective TCR-dependent responses of human colonic Vg4+ cells. Hence, a conserved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell compartments.

U2 - 10.1016/j.cell.2016.08.030

DO - 10.1016/j.cell.2016.08.030

M3 - Article

SN - 0092-8674

VL - 167

SP - 203-218.e17

JO - Cell

JF - Cell

IS - 1

ER -

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

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