Epithelial discrimination of commensal and pathogenic Candida albicans

SX Tang, DL Moyes, JP Richardson, M Blagojevic, JR Naglik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

All mucosal surfaces are lined by epithelial cells and are colonised by opportunistic microbes. In health, these opportunistic microbes remain commensal and are tolerated by the immune system. However, when the correct environmental conditions arise, these microbes can become pathogenic and need to be controlled or cleared by the immune system to prevent disease. The mechanisms that enable epithelial cells to initiate the 'danger' signals activated specifically by pathogenic microbes are critical to mucosal defence and homeostasis but are not well understood. Deciphering these mechanisms will provide essential understanding to how mucosal tissues maintain health and activate immunity, as well as how pathogens promote disease. This review focuses on the interaction of the human fungal pathogen Candida albicans with epithelial cells and the epithelial mechanisms that enable mucosal tissues to discriminate between the commensal and pathogenic state of this medically important fungus.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalOral Diseases
Volume22
Issue numberS1
Early online date4 Feb 2016
DOIs
Publication statusPublished - Apr 2016

Keywords

  • C-Fos
  • Candida albicans
  • Epithelium
  • Immunity
  • Innate
  • MAPK

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