King's College London

Research portal

Equivocal, explicit and emergent actions of PKC isoforms in cancer

Research output: Contribution to journalReview articlepeer-review

Peter J. Parker, Sophie J. Brown, Veronique Calleja, Probir Chakravarty, Mathias Cobbaut, Mark Linch, Jacqueline J.T. Marshall, Silvia Martini, Neil Q. McDonald, Tanya Soliman, Lisa Watson

Original languageEnglish
Pages (from-to)51-63
Number of pages13
Issue number1
Accepted/In press2020
PublishedJan 2021

Bibliographical note

Funding Information: The authors thank A. Fields and M. Reyland for commenting on the manuscript. They also acknowledge support from the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130). M.L. is supported by the National Institute for Health Research, the University College London Hospitals Biomedical Research Centre (no grant numbers apply). Publisher Copyright: © 2020, Springer Nature Limited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


The maturing mutational landscape of cancer genomes, the development and application of clinical interventions and evolving insights into tumour-associated functions reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints and plasticity impact this class of proteins and how emergent cancer-associated properties may offer opportunities for intervention. The profound impact of the tumour microenvironment, reflected in the efficacy of immune checkpoint interventions, further prompts to incorporate PKC family actions and interventions in this ecosystem, informed by insights into the control of stromal and immune cell functions. Drugging PKC isoforms has offered much promise, but when and how is not obvious.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454