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ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK

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ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK. / the BRIGHT project team.

In: NeuroImage, Vol. 210, 116591, 15.04.2020.

Research output: Contribution to journalArticle

Harvard

the BRIGHT project team 2020, 'ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK', NeuroImage, vol. 210, 116591. https://doi.org/10.1016/j.neuroimage.2020.116591

APA

the BRIGHT project team (2020). ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK. NeuroImage, 210, [116591]. https://doi.org/10.1016/j.neuroimage.2020.116591

Vancouver

the BRIGHT project team. ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK. NeuroImage. 2020 Apr 15;210. 116591. https://doi.org/10.1016/j.neuroimage.2020.116591

Author

the BRIGHT project team. / ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK. In: NeuroImage. 2020 ; Vol. 210.

Bibtex Download

@article{2dec249242844f0c903bc6cfe7ad9876,
title = "ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK",
abstract = "Introduction: Infants and children in low- and middle-income countries are frequently exposed to a range of poverty-related risk factors, increasing their likelihood of poor neurodevelopmental outcomes. There is a need for culturally objective markers, which can be used to study infants from birth, thereby enabling early identification and ultimately intervention during a critical time of neurodevelopment. Method: In this paper, we investigate developmental changes in auditory event related potentials (ERP) associated with habituation and novelty detection in infants between 1 and 5 months living in the United Kingdom and The Gambia, West Africa. Previous research reports that whereas newborns’ ERP responses are increased when presented with stimuli of higher intensity, this sensory driven response decreases over the first few months of life, giving rise to a cognitively driven, novelty-based response. Anthropometric measures were obtained concurrently with the ERP measures at 1 and 5 months of age. Neurodevelopmental outcome was measured using the Mullen Scales of Early Learning (MSEL) at 5 months of age. Results: The described developmental change was observed in the UK cohort, who exhibited an intensity-based response at 1 month and a novelty-based response at 5 months of age. This change was accompanied by greater habituation to stimulus intensity at 5 compared to 1 month. In the Gambian cohort we did not see a change from an intensity-to a novelty-based response, and no change in habituation to stimulus intensity across the two age points. The degree of change from an intensity towards a novelty-based response was further found to be associated with MSEL scores at 5 months of infant age, whereas infants’ growth between 1 and 5 months was not. Discussion: Our study highlights the utility of ERP-based markers to study young infants in rural Africa. By implementing a well-established paradigm in a previously understudied population we have demonstrated its use as a culturally objective tool to better understand early learning in diverse settings world-wide. Results offer insight into the neurodevelopmental processes underpinning early neurocognitive development, which may in the future contribute to early identification of infants at heightened risk of adverse neurodevelopmental outcome.",
keywords = "Event related potentials, Global health, Habituation, Infants, Neurodevelopment, Novelty detection",
author = "{the BRIGHT project team} and Laura Katus and Luke Mason and Bosiljka Milosavljevic and Samantha McCann and Maria Rozhko and Moore, {Sophie E.} and Elwell, {Clare E.} and Sarah Lloyd-Fox and {de Haan}, Michelle and Saikou Drammeh and Ebrima Mbye and Ebou Touray and Mohammed Ceesay and Buba Jobarteh and Darboe, {Momodou K.} and Topun Austin and Andrew Prentice",
year = "2020",
month = "4",
day = "15",
doi = "10.1016/j.neuroimage.2020.116591",
language = "English",
volume = "210",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK

AU - the BRIGHT project team

AU - Katus, Laura

AU - Mason, Luke

AU - Milosavljevic, Bosiljka

AU - McCann, Samantha

AU - Rozhko, Maria

AU - Moore, Sophie E.

AU - Elwell, Clare E.

AU - Lloyd-Fox, Sarah

AU - de Haan, Michelle

AU - Drammeh, Saikou

AU - Mbye, Ebrima

AU - Touray, Ebou

AU - Ceesay, Mohammed

AU - Jobarteh, Buba

AU - Darboe, Momodou K.

AU - Austin, Topun

AU - Prentice, Andrew

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Introduction: Infants and children in low- and middle-income countries are frequently exposed to a range of poverty-related risk factors, increasing their likelihood of poor neurodevelopmental outcomes. There is a need for culturally objective markers, which can be used to study infants from birth, thereby enabling early identification and ultimately intervention during a critical time of neurodevelopment. Method: In this paper, we investigate developmental changes in auditory event related potentials (ERP) associated with habituation and novelty detection in infants between 1 and 5 months living in the United Kingdom and The Gambia, West Africa. Previous research reports that whereas newborns’ ERP responses are increased when presented with stimuli of higher intensity, this sensory driven response decreases over the first few months of life, giving rise to a cognitively driven, novelty-based response. Anthropometric measures were obtained concurrently with the ERP measures at 1 and 5 months of age. Neurodevelopmental outcome was measured using the Mullen Scales of Early Learning (MSEL) at 5 months of age. Results: The described developmental change was observed in the UK cohort, who exhibited an intensity-based response at 1 month and a novelty-based response at 5 months of age. This change was accompanied by greater habituation to stimulus intensity at 5 compared to 1 month. In the Gambian cohort we did not see a change from an intensity-to a novelty-based response, and no change in habituation to stimulus intensity across the two age points. The degree of change from an intensity towards a novelty-based response was further found to be associated with MSEL scores at 5 months of infant age, whereas infants’ growth between 1 and 5 months was not. Discussion: Our study highlights the utility of ERP-based markers to study young infants in rural Africa. By implementing a well-established paradigm in a previously understudied population we have demonstrated its use as a culturally objective tool to better understand early learning in diverse settings world-wide. Results offer insight into the neurodevelopmental processes underpinning early neurocognitive development, which may in the future contribute to early identification of infants at heightened risk of adverse neurodevelopmental outcome.

AB - Introduction: Infants and children in low- and middle-income countries are frequently exposed to a range of poverty-related risk factors, increasing their likelihood of poor neurodevelopmental outcomes. There is a need for culturally objective markers, which can be used to study infants from birth, thereby enabling early identification and ultimately intervention during a critical time of neurodevelopment. Method: In this paper, we investigate developmental changes in auditory event related potentials (ERP) associated with habituation and novelty detection in infants between 1 and 5 months living in the United Kingdom and The Gambia, West Africa. Previous research reports that whereas newborns’ ERP responses are increased when presented with stimuli of higher intensity, this sensory driven response decreases over the first few months of life, giving rise to a cognitively driven, novelty-based response. Anthropometric measures were obtained concurrently with the ERP measures at 1 and 5 months of age. Neurodevelopmental outcome was measured using the Mullen Scales of Early Learning (MSEL) at 5 months of age. Results: The described developmental change was observed in the UK cohort, who exhibited an intensity-based response at 1 month and a novelty-based response at 5 months of age. This change was accompanied by greater habituation to stimulus intensity at 5 compared to 1 month. In the Gambian cohort we did not see a change from an intensity-to a novelty-based response, and no change in habituation to stimulus intensity across the two age points. The degree of change from an intensity towards a novelty-based response was further found to be associated with MSEL scores at 5 months of infant age, whereas infants’ growth between 1 and 5 months was not. Discussion: Our study highlights the utility of ERP-based markers to study young infants in rural Africa. By implementing a well-established paradigm in a previously understudied population we have demonstrated its use as a culturally objective tool to better understand early learning in diverse settings world-wide. Results offer insight into the neurodevelopmental processes underpinning early neurocognitive development, which may in the future contribute to early identification of infants at heightened risk of adverse neurodevelopmental outcome.

KW - Event related potentials

KW - Global health

KW - Habituation

KW - Infants

KW - Neurodevelopment

KW - Novelty detection

UR - http://www.scopus.com/inward/record.url?scp=85078843375&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2020.116591

DO - 10.1016/j.neuroimage.2020.116591

M3 - Article

C2 - 32007497

AN - SCOPUS:85078843375

VL - 210

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116591

ER -

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