ERS International Congress 2021: highlights from the Paediatric Assembly

Cristina Ardura-Garcia; Alicia Abellan; Sara Cuevas-Ocaña; Nadine Freitag; Yin Ting Lam; Heidi Makrinioti; Monique Slaats; Matteo Storti; Emma E. Williams; Theodore Dassios; Liesbeth Duijts; Refika H. Ersu; Stojka Fustik; Rory E. Morty; Marijke Proesmans; Dirk Schramm; Sejal Saglani; Alexander Moeller; Marielle W. Pijnenburg

doi:10.1183/23120541.00643-2021

ERS International Congress 2021: highlights from the Paediatric Assembly

Cristina Ardura-Garcia^*, Alicia Abellan, Sara Cuevas-Ocaña, Nadine Freitag, Yin Ting Lam, Heidi Makrinioti, Monique Slaats, Matteo Storti, Emma E. Williams, Theodore Dassios, Liesbeth Duijts, Refika H. Ersu, Stojka Fustik, Rory E. Morty, Marijke Proesmans, Dirk Schramm, Sejal Saglani, Alexander Moeller, Marielle W. Pijnenburg

^*Corresponding author for this work

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In this review, Early Career Members of the European Respiratory Society (ERS) and the Chairs of the ERS Assembly 7: Paediatrics present the highlights in paediatric respiratory medicine from the ERS International Congress 2021. The eight scientific Groups of this Assembly cover respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway development. We here describe new developments in lung function testing and sleep-disordered breathing diagnosis, early life exposures affecting pulmonary function in children and effect of COVID-19 on sleep and lung function. In paediatric asthma, we present the important role of the exposome in asthma development, and how biologics can provide better outcomes. We discuss new methods to assess distal airways in children with CF, as some details remain blind when using the lung clearance index. Moreover, we summarise the new ERS guidelines for bronchiectasis management in children and adolescents. We present interventions to reduce morbidity and monitor pulmonary function in newborns at risk of bronchopulmonary dysplasia and long-term chronic respiratory morbidity of this disease. In respiratory epidemiology, we characterise primary ciliary dyskinesia, identify early life determinants of respiratory health and describe the effect of COVID-19 preventive measures on respiratory symptoms. Also, we describe the epidemiology of interstitial lung diseases, possible consequences of tracheomalacia and a classification of diffuse alveolar haemorrhage in children. Finally, we highlight that the characterisation of genes and pathways involved in the development of a disease is essential to identify new biomarkers and therapeutic targets.

Original language	English
Article number	00643-2021
Journal	ERJ Open Research
Volume	8
Issue number	2
DOIs	https://doi.org/10.1183/23120541.00643-2021
Publication status	Published - 1 Apr 2022

Access to Document

10.1183/23120541.00643-2021

Cite this

Ardura-Garcia, C., Abellan, A., Cuevas-Ocaña, S., Freitag, N., Lam, Y. T., Makrinioti, H., Slaats, M., Storti, M., Williams, E. E., Dassios, T., Duijts, L., Ersu, R. H., Fustik, S., Morty, R. E., Proesmans, M., Schramm, D., Saglani, S., Moeller, A., & Pijnenburg, M. W. (2022). ERS International Congress 2021: highlights from the Paediatric Assembly. ERJ Open Research, 8(2), Article 00643-2021. https://doi.org/10.1183/23120541.00643-2021

@article{606c7b60eef0456e97e5c33062ddb138,

title = "ERS International Congress 2021: highlights from the Paediatric Assembly",

abstract = "In this review, Early Career Members of the European Respiratory Society (ERS) and the Chairs of the ERS Assembly 7: Paediatrics present the highlights in paediatric respiratory medicine from the ERS International Congress 2021. The eight scientific Groups of this Assembly cover respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway development. We here describe new developments in lung function testing and sleep-disordered breathing diagnosis, early life exposures affecting pulmonary function in children and effect of COVID-19 on sleep and lung function. In paediatric asthma, we present the important role of the exposome in asthma development, and how biologics can provide better outcomes. We discuss new methods to assess distal airways in children with CF, as some details remain blind when using the lung clearance index. Moreover, we summarise the new ERS guidelines for bronchiectasis management in children and adolescents. We present interventions to reduce morbidity and monitor pulmonary function in newborns at risk of bronchopulmonary dysplasia and long-term chronic respiratory morbidity of this disease. In respiratory epidemiology, we characterise primary ciliary dyskinesia, identify early life determinants of respiratory health and describe the effect of COVID-19 preventive measures on respiratory symptoms. Also, we describe the epidemiology of interstitial lung diseases, possible consequences of tracheomalacia and a classification of diffuse alveolar haemorrhage in children. Finally, we highlight that the characterisation of genes and pathways involved in the development of a disease is essential to identify new biomarkers and therapeutic targets.",

author = "Cristina Ardura-Garcia and Alicia Abellan and Sara Cuevas-Oca{\~n}a and Nadine Freitag and Lam, {Yin Ting} and Heidi Makrinioti and Monique Slaats and Matteo Storti and Williams, {Emma E.} and Theodore Dassios and Liesbeth Duijts and Ersu, {Refika H.} and Stojka Fustik and Morty, {Rory E.} and Marijke Proesmans and Dirk Schramm and Sejal Saglani and Alexander Moeller and Pijnenburg, {Marielle W.}",

note = "Funding Information: Conflict of interest: C. Ardura-Garcia is supported by the Swiss National Science Foundation (grant number 32003B_162820), support for attending meetings from the ERS, and is the Early Career Member Representative of the Paediatrics Assembly of the European Respiratory Society (ERS). S. Cuevas-Oca{\~n}a has received support for attending meetings from the ERS. M. Slaats received funding from Chiesi Pharmaceutical S.p.a. for his PhD studies. R.E. Morty has received grants or contracts from Deutsche Forschungsgemeinschaft, the Max Planck Society, Universit{\"a}tsklinikum Heidelberg, and Bundesministerium f{\"u}r Bildung und Forschung; honoraria as the Editor-in-Chief of the American Journal of Physiology – Lung Cellular and Molecular Physiology; has a role as director of the International Graduate Programme, Molecular Biology and Medicine of the Lung, coordinator of the German Center for Lung Research Academy, Vice-Chair of the Gordon Conference of Lung Injury, Development, and Repair 2021, Chair of the Group 07.08 of the ERS, Chair of the Dept of Translational Pulmonology at the University Hospital Heidelberg. A. Moeller has received consulting fees from Vertex Inc., lecture fees from Vertex Inc. and Vifor Inc., has participated in the advisory board for Vertex Inc., and is the Secretary of the ERS Paediatric Assembly. M.W. Pijnenburg has received grants or contracts from Lung Foundation Netherlands and the Netherlands Organisation for Health Research and Development, consultation fees from Sanofi, honoraria as a speaker from Abbvie and Novartis, and support for attending meetings from the ERS. All other authors have nothing to disclose. Funding Information: Support statement: C. Ardura-Garcia is supported by the Swiss National Science Foundation 32003B_162820). M. Storti is supported by Chiesi Pharmaceutical S.p.a. Publisher Copyright: {\textcopyright} The authors 2022.",

year = "2022",

month = apr,

day = "1",

doi = "10.1183/23120541.00643-2021",

language = "English",

volume = "8",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "European Respiratory Society",

number = "2",

}

Ardura-Garcia, C, Abellan, A, Cuevas-Ocaña, S, Freitag, N, Lam, YT, Makrinioti, H, Slaats, M, Storti, M, Williams, EE, Dassios, T, Duijts, L, Ersu, RH, Fustik, S, Morty, RE, Proesmans, M, Schramm, D, Saglani, S, Moeller, A & Pijnenburg, MW 2022, 'ERS International Congress 2021: highlights from the Paediatric Assembly', ERJ Open Research, vol. 8, no. 2, 00643-2021. https://doi.org/10.1183/23120541.00643-2021

TY - JOUR

T1 - ERS International Congress 2021

T2 - highlights from the Paediatric Assembly

AU - Ardura-Garcia, Cristina

AU - Abellan, Alicia

AU - Cuevas-Ocaña, Sara

AU - Freitag, Nadine

AU - Lam, Yin Ting

AU - Makrinioti, Heidi

AU - Slaats, Monique

AU - Storti, Matteo

AU - Williams, Emma E.

AU - Dassios, Theodore

AU - Duijts, Liesbeth

AU - Ersu, Refika H.

AU - Fustik, Stojka

AU - Morty, Rory E.

AU - Proesmans, Marijke

AU - Schramm, Dirk

AU - Saglani, Sejal

AU - Moeller, Alexander

AU - Pijnenburg, Marielle W.

N1 - Funding Information: Conflict of interest: C. Ardura-Garcia is supported by the Swiss National Science Foundation (grant number 32003B_162820), support for attending meetings from the ERS, and is the Early Career Member Representative of the Paediatrics Assembly of the European Respiratory Society (ERS). S. Cuevas-Ocaña has received support for attending meetings from the ERS. M. Slaats received funding from Chiesi Pharmaceutical S.p.a. for his PhD studies. R.E. Morty has received grants or contracts from Deutsche Forschungsgemeinschaft, the Max Planck Society, Universitätsklinikum Heidelberg, and Bundesministerium für Bildung und Forschung; honoraria as the Editor-in-Chief of the American Journal of Physiology – Lung Cellular and Molecular Physiology; has a role as director of the International Graduate Programme, Molecular Biology and Medicine of the Lung, coordinator of the German Center for Lung Research Academy, Vice-Chair of the Gordon Conference of Lung Injury, Development, and Repair 2021, Chair of the Group 07.08 of the ERS, Chair of the Dept of Translational Pulmonology at the University Hospital Heidelberg. A. Moeller has received consulting fees from Vertex Inc., lecture fees from Vertex Inc. and Vifor Inc., has participated in the advisory board for Vertex Inc., and is the Secretary of the ERS Paediatric Assembly. M.W. Pijnenburg has received grants or contracts from Lung Foundation Netherlands and the Netherlands Organisation for Health Research and Development, consultation fees from Sanofi, honoraria as a speaker from Abbvie and Novartis, and support for attending meetings from the ERS. All other authors have nothing to disclose. Funding Information: Support statement: C. Ardura-Garcia is supported by the Swiss National Science Foundation 32003B_162820). M. Storti is supported by Chiesi Pharmaceutical S.p.a. Publisher Copyright: © The authors 2022.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - In this review, Early Career Members of the European Respiratory Society (ERS) and the Chairs of the ERS Assembly 7: Paediatrics present the highlights in paediatric respiratory medicine from the ERS International Congress 2021. The eight scientific Groups of this Assembly cover respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway development. We here describe new developments in lung function testing and sleep-disordered breathing diagnosis, early life exposures affecting pulmonary function in children and effect of COVID-19 on sleep and lung function. In paediatric asthma, we present the important role of the exposome in asthma development, and how biologics can provide better outcomes. We discuss new methods to assess distal airways in children with CF, as some details remain blind when using the lung clearance index. Moreover, we summarise the new ERS guidelines for bronchiectasis management in children and adolescents. We present interventions to reduce morbidity and monitor pulmonary function in newborns at risk of bronchopulmonary dysplasia and long-term chronic respiratory morbidity of this disease. In respiratory epidemiology, we characterise primary ciliary dyskinesia, identify early life determinants of respiratory health and describe the effect of COVID-19 preventive measures on respiratory symptoms. Also, we describe the epidemiology of interstitial lung diseases, possible consequences of tracheomalacia and a classification of diffuse alveolar haemorrhage in children. Finally, we highlight that the characterisation of genes and pathways involved in the development of a disease is essential to identify new biomarkers and therapeutic targets.

AB - In this review, Early Career Members of the European Respiratory Society (ERS) and the Chairs of the ERS Assembly 7: Paediatrics present the highlights in paediatric respiratory medicine from the ERS International Congress 2021. The eight scientific Groups of this Assembly cover respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway development. We here describe new developments in lung function testing and sleep-disordered breathing diagnosis, early life exposures affecting pulmonary function in children and effect of COVID-19 on sleep and lung function. In paediatric asthma, we present the important role of the exposome in asthma development, and how biologics can provide better outcomes. We discuss new methods to assess distal airways in children with CF, as some details remain blind when using the lung clearance index. Moreover, we summarise the new ERS guidelines for bronchiectasis management in children and adolescents. We present interventions to reduce morbidity and monitor pulmonary function in newborns at risk of bronchopulmonary dysplasia and long-term chronic respiratory morbidity of this disease. In respiratory epidemiology, we characterise primary ciliary dyskinesia, identify early life determinants of respiratory health and describe the effect of COVID-19 preventive measures on respiratory symptoms. Also, we describe the epidemiology of interstitial lung diseases, possible consequences of tracheomalacia and a classification of diffuse alveolar haemorrhage in children. Finally, we highlight that the characterisation of genes and pathways involved in the development of a disease is essential to identify new biomarkers and therapeutic targets.

UR - http://www.scopus.com/inward/record.url?scp=85131156566&partnerID=8YFLogxK

U2 - 10.1183/23120541.00643-2021

DO - 10.1183/23120541.00643-2021

M3 - Article

AN - SCOPUS:85131156566

SN - 2312-0541

VL - 8

JO - ERJ Open Research

JF - ERJ Open Research

IS - 2

M1 - 00643-2021

ER -

ERS International Congress 2021: highlights from the Paediatric Assembly

Abstract

Access to Document

Other files and links

Fingerprint

Cite this