Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

C Houart, L Caneparo, C P Heisenberg, K A Barth, M Take-Uchi, S W Wilson

Research output: Contribution to journalArticlepeer-review

262 Citations (Scopus)


Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.
Original languageEnglish
Pages (from-to)255 - 265
Number of pages11
Issue number2
Publication statusPublished - 18 Jul 2002


Dive into the research topics of 'Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling'. Together they form a unique fingerprint.

Cite this