Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

C Houart; L Caneparo; C P Heisenberg; K A Barth; M Take-Uchi; S W Wilson

doi:10.1016/S0896-6273(02)00751-1

Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

C Houart, L Caneparo, C P Heisenberg, K A Barth, M Take-Uchi, S W Wilson

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

271 Citations (Scopus)

Abstract

Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

Original language	English
Pages (from-to)	255 - 265
Number of pages	11
Journal	Neuron
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/S0896-6273(02)00751-1
Publication status	Published - 18 Jul 2002

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title = "Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling",

abstract = "Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.",

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AU - Houart, C

AU - Caneparo, L

AU - Heisenberg, C P

AU - Barth, K A

AU - Take-Uchi, M

AU - Wilson, S W

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AB - Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

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Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

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