Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

TY - JOUR

T1 - Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling

AU - Houart, C

AU - Caneparo, L

AU - Heisenberg, C P

AU - Barth, K A

AU - Take-Uchi, M

AU - Wilson, S W

PY - 2002/7/18

Y1 - 2002/7/18

N2 - Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

AB - Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

UR - https://www.scopus.com/pages/publications/0037130459

U2 - 10.1016/S0896-6273(02)00751-1

DO - 10.1016/S0896-6273(02)00751-1

M3 - Article

VL - 35

SP - 255

EP - 265

JO - Neuron

JF - Neuron

IS - 2

ER -