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Ethnic differences in arterial responses and inflammatory markers in Afro-Caribbean and Caucasian subjects

Research output: Contribution to journalArticle

L Kalra, C Rambaran, P Chowienczyk, D Goss, I Hambleton, J Ritter, A Shah, R Wilks, T Forrester

Original languageEnglish
Pages (from-to)2362 - 2367
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number11
Publication statusPublished - Nov 2005

King's Authors


Objective-Small vessel disease is more common in Afro-Caribbeans than Caucasians. We investigated underlying differences in metabolic, inflammatory, and vascular responses that may predispose Afro-Caribbeans to small vessel pathology. Methods and Results-Seventy-eight Afro-Caribbeans aged 35-75 years, with no vascular disease or medications, were compared with 82 matched Caucasians for metabolic variables, fasting insulin, interleukin 6, tumor necrosis factor (TNF) alpha, and cytoplasmic repressor protein levels. Carotid intima media thickness (CIMT) was measured ultrasonographically. Small vessel function was assessed by measuring the absolute change from baseline in the reflectance index (RI) of the digital volume pulse during IV infusion of albuterol (5 mu g/min, Delta RIALB) and glyceryl tri nitrate (5 mu g/min, Delta RIGTN). Large artery elasticity was measured as the stiffness index (SI) and derived from the time to pulse wave reflection adjusted for subject height. Afro-Caribbeans had significantly higher diastolic blood pressure (80.3 versus 77.6 mm Hg; P=0.033), fasting insulin (14.0 versus 10.6 mu U/mL; P=0.026), TNF-alpha(6.7 versus 4.3; pg/mL; P=0.001), and interleukin 6 (2.3 versus 1.5 pg/mL; P=0.036) levels compared with Caucasians. CIMT was greater (0.81 +/- 0.20 versus 0.75 +/- 0.18 mm; P=0.02) and small vessel reactivity attenuated (mean Delta RIALB 6.8 +/- 8.0% versus 12.3 +/- 8.%; P

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