Ethnic differences in markers of thrombophilia - Implications for the investigation of ischemic stroke in multiethnic populations: The South London Ethnicity and Stroke Study

P Jerrard-Dunne, A Evans, R McGovern, C Hajat, L Kalra, A G Rudd, C D Wolfe, H S Markus

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Background and Purpose-The role of hypercoagulable states in the pathogenesis of ischemic stroke in black subjects is not known, and data on normal reference ranges in black populations are lacking. This study estimated ethnic-specific reference ranges in a community population to determine the prevalence of thrombophilic states in a multiethnic stroke population. Methods-Free protein S, protein C, antithrombin III, activated protein C resistance, IgG anticardiolipin antibodies, and lupus anticoagulant were determined in 130 consecutive ischemic stroke cases less than or equal to65 years of age (50 black Caribbeans, 30 black Africans, 50 whites) and 130 community controls. Results-Black African controls had significantly lower protein S (P
Original languageEnglish
Pages (from-to)1821 - 1826
Number of pages6
JournalStroke
Volume34
Issue number8
DOIs
Publication statusPublished - 1 Aug 2003

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