EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort

Johan Isaksson; Kristiina Tammimies; Janina Neufeld; Élodie Cauvet; Karl Lundin; Jan K. Buitelaar; Eva Loth; Declan G.M. Murphy; Will Spooren; Sven Bölte; Jumana Ahmad; Sara Ambrosino; Bonnie Auyeung; Tobias Banaschewski; Simon Baron-Cohen; Sarah Baumeister; Christian Beckmann; Thomas Bourgeron; Carsten Bours; Michael Brammer; Daniel Brandeis; Claudia Brogna; Yvette De Bruijn; Bhismadev Chakrabarti; Tony Charman; Daisy Crawley; Ineke Cornelissen; Flavio Dell'Acqua; Guillaume Dumas; Sarah Durston; Christine Ecker; Vincent Frouin; Pilar Garcés; David Goyard; Lindsay Ham; Hannah Hayward; Joerg Hipp; Rosemary J. Holt; Mark H. Johnson; Emily J.H. Jones; Prantik Kundu; Meng Chuan Lai; Xavier Liogier D'Ardhuy; Michael Lombardo; David J. Lythgoe; Barbara Ruggeri; Antonia San José Cáceres; Emily Simonoff; Julian Tillmann; Steve C.R. Williams

doi:10.1186/s13229-018-0212-x

EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort

Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G.M. Murphy, Will Spooren, Sven Bölte^*, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Thomas Bourgeron, Carsten Bours, Michael BrammerDaniel Brandeis, Claudia Brogna, Yvette De Bruijn, Bhismadev Chakrabarti, Tony Charman, Daisy Crawley, Ineke Cornelissen, Flavio Dell'Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J. Holt, Mark H. Johnson, Emily J.H. Jones, Prantik Kundu, Meng Chuan Lai, Xavier Liogier D'Ardhuy, Michael Lombardo, David J. Lythgoe, Barbara Ruggeri, Antonia San José Cáceres, Emily Simonoff, Julian Tillmann, Steve C.R. Williams

^*Corresponding author for this work

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Abstract

EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.

Original language	English
Article number	26
Journal	Molecular Autism
Volume	9
Issue number	1
Early online date	13 Apr 2018
DOIs	https://doi.org/10.1186/s13229-018-0212-x
Publication status	E-pub ahead of print - 13 Apr 2018

Keywords

ADHD
Autism spectrum disorder
Biomarkers
Brain
Cognition
Europe
Genetics
Intervention
Twins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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EU-AIMS Isaksson Accepted 1Apr2018 GOLD VoR CCBYFinal published version, 549 KBLicence: CC BY

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Isaksson, J., Tammimies, K., Neufeld, J., Cauvet, É., Lundin, K., Buitelaar, J. K., Loth, E., Murphy, D. G. M., Spooren, W., Bölte, S., Ahmad, J., Ambrosino, S., Auyeung, B., Banaschewski, T., Baron-Cohen, S., Baumeister, S., Beckmann, C., Bourgeron, T., Bours, C., ... Williams, S. C. R. (2018). EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort. Molecular Autism, 9(1), Article 26. Advance online publication. https://doi.org/10.1186/s13229-018-0212-x

@article{b309dc2e40714430b5e58812ed265e26,

title = "EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort",

abstract = "EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.",

keywords = "ADHD, Autism spectrum disorder, Biomarkers, Brain, Cognition, Europe, Genetics, Intervention, Twins",

author = "Johan Isaksson and Kristiina Tammimies and Janina Neufeld and {\'E}lodie Cauvet and Karl Lundin and Buitelaar, {Jan K.} and Eva Loth and Murphy, {Declan G.M.} and Will Spooren and Sven B{\"o}lte and Jumana Ahmad and Sara Ambrosino and Bonnie Auyeung and Tobias Banaschewski and Simon Baron-Cohen and Sarah Baumeister and Christian Beckmann and Thomas Bourgeron and Carsten Bours and Michael Brammer and Daniel Brandeis and Claudia Brogna and {De Bruijn}, Yvette and Bhismadev Chakrabarti and Tony Charman and Daisy Crawley and Ineke Cornelissen and Flavio Dell'Acqua and Guillaume Dumas and Sarah Durston and Christine Ecker and Vincent Frouin and Pilar Garc{\'e}s and David Goyard and Lindsay Ham and Hannah Hayward and Joerg Hipp and Holt, {Rosemary J.} and Johnson, {Mark H.} and Jones, {Emily J.H.} and Prantik Kundu and Lai, {Meng Chuan} and D'Ardhuy, {Xavier Liogier} and Michael Lombardo and Lythgoe, {David J.} and Barbara Ruggeri and C{\'a}ceres, {Antonia San Jos{\'e}} and Emily Simonoff and Julian Tillmann and Williams, {Steve C.R.}",

year = "2018",

month = apr,

day = "13",

doi = "10.1186/s13229-018-0212-x",

language = "English",

volume = "9",

journal = "Molecular Autism",

issn = "2040-2392",

publisher = "BioMed Central",

number = "1",

}

Isaksson, J, Tammimies, K, Neufeld, J, Cauvet, É, Lundin, K, Buitelaar, JK, Loth, E , Murphy, DGM, Spooren, W, Bölte, S, Ahmad, J, Ambrosino, S, Auyeung, B, Banaschewski, T, Baron-Cohen, S, Baumeister, S, Beckmann, C, Bourgeron, T, Bours, C, Brammer, M, Brandeis, D, Brogna, C, De Bruijn, Y, Chakrabarti, B, Charman, T , Crawley, D, Cornelissen, I, Dell'Acqua, F, Dumas, G, Durston, S, Ecker, C, Frouin, V, Garcés, P, Goyard, D, Ham, L, Hayward, H, Hipp, J, Holt, RJ, Johnson, MH, Jones, EJH, Kundu, P, Lai, MC, D'Ardhuy, XL, Lombardo, M, Lythgoe, DJ , Ruggeri, B , Cáceres, ASJ , Simonoff, E , Tillmann, J & Williams, SCR 2018, 'EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort', Molecular Autism, vol. 9, no. 1, 26. https://doi.org/10.1186/s13229-018-0212-x

TY - JOUR

T1 - EU-AIMS Longitudinal European Autism Project (LEAP)

T2 - The autism twin cohort

AU - Isaksson, Johan

AU - Tammimies, Kristiina

AU - Neufeld, Janina

AU - Cauvet, Élodie

AU - Lundin, Karl

AU - Buitelaar, Jan K.

AU - Loth, Eva

AU - Murphy, Declan G.M.

AU - Spooren, Will

AU - Bölte, Sven

AU - Ahmad, Jumana

AU - Ambrosino, Sara

AU - Auyeung, Bonnie

AU - Banaschewski, Tobias

AU - Baron-Cohen, Simon

AU - Baumeister, Sarah

AU - Beckmann, Christian

AU - Bourgeron, Thomas

AU - Bours, Carsten

AU - Brammer, Michael

AU - Brandeis, Daniel

AU - Brogna, Claudia

AU - De Bruijn, Yvette

AU - Chakrabarti, Bhismadev

AU - Charman, Tony

AU - Crawley, Daisy

AU - Cornelissen, Ineke

AU - Dell'Acqua, Flavio

AU - Dumas, Guillaume

AU - Durston, Sarah

AU - Ecker, Christine

AU - Frouin, Vincent

AU - Garcés, Pilar

AU - Goyard, David

AU - Ham, Lindsay

AU - Hayward, Hannah

AU - Hipp, Joerg

AU - Holt, Rosemary J.

AU - Johnson, Mark H.

AU - Jones, Emily J.H.

AU - Kundu, Prantik

AU - Lai, Meng Chuan

AU - D'Ardhuy, Xavier Liogier

AU - Lombardo, Michael

AU - Lythgoe, David J.

AU - Ruggeri, Barbara

AU - Cáceres, Antonia San José

AU - Simonoff, Emily

AU - Tillmann, Julian

AU - Williams, Steve C.R.

PY - 2018/4/13

Y1 - 2018/4/13

N2 - EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.

AB - EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.

KW - ADHD

KW - Autism spectrum disorder

KW - Biomarkers

KW - Brain

KW - Cognition

KW - Europe

KW - Genetics

KW - Intervention

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=85045403786&partnerID=8YFLogxK

U2 - 10.1186/s13229-018-0212-x

DO - 10.1186/s13229-018-0212-x

M3 - Article

AN - SCOPUS:85045403786

SN - 2040-2392

VL - 9

JO - Molecular Autism

JF - Molecular Autism

IS - 1

M1 - 26

ER -

EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort

Abstract

Keywords

UN SDGs

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