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EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort

Research output: Contribution to journalArticle

Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G.M. Murphy, Will Spooren, Sven Bölte, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Thomas Bourgeron, Carsten Bours, Michael Brammer & 30 more Daniel Brandeis, Claudia Brogna, Yvette De Bruijn, Bhismadev Chakrabarti, Tony Charman, Daisy Crawley, Ineke Cornelissen, Flavio Dell'Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J. Holt, Mark H. Johnson, Emily J.H. Jones, Prantik Kundu, Meng Chuan Lai, Xavier Liogier D'Ardhuy, Michael Lombardo, David J. Lythgoe, Barbara Ruggeri, Antonia San José Cáceres, Emily Simonoff, Julian Tillmann, Steve C.R. Williams

Original languageEnglish
Article number26
JournalMolecular Autism
Volume9
Issue number1
Early online date13 Apr 2018
DOIs
Publication statusE-pub ahead of print - 13 Apr 2018

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Abstract

EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.

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