European Neuromuscular Centre consensus statement on anaesthesia in patients with neuromuscular disorders

TY - JOUR

T1 - European Neuromuscular Centre consensus statement on anaesthesia in patients with neuromuscular disorders

AU - van den Bersselaar, Luuk R

AU - Heytens, Luc

AU - Silva, Helga C A

AU - Reimann, Jens

AU - Tasca, Giorgio

AU - Díaz-Cambronero, Óscar

AU - Løkken, Nicoline

AU - Hellblom, Anna

AU - Hopkins, Philip M

AU - Rueffert, Henrik

AU - Bastian, Börge

AU - Vilchez, Juan Jesus

AU - Gillies, Robyn

AU - Johannsen, Stephan

AU - Veyckemans, Francis

AU - Muenster, Tino

AU - Klein, Andrea

AU - Litman, Ron

AU - Jungbluth, Heinz

AU - Riazi, Sheila

AU - Voermans, Nicol C

AU - Snoeck, Marc M J

N1 - Funding Information: We are thankful to the ENMC, which financially supported the 259th ENMC workshop. Several authors are members of the Radboud‐NMD, NL‐NMD, EURO‐NMD, and TREAT‐NMD consortium. We would like to dedicate this consensus statement to the late Professor Ron Litman, who participated in and contributed to the first workshop session. Publisher Copyright: © 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

PY - 2022/12

Y1 - 2022/12

N2 - BACKGROUND AND PURPOSE: Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these patients. Here, we present the European Neuromuscular Centre (ENMC) consensus statement on anaesthesia in patients with neuromuscular disorders as formulated during the 259th ENMC Workshop on Anaesthesia in Neuromuscular Disorders.METHODS: International experts in the field of (paediatric) anaesthesia, neurology, and genetics were invited to participate in the ENMC workshop. A literature search was conducted in PubMed and Embase, the main findings of which were disseminated to the participants and presented during the workshop. Depending on specific expertise, participants presented the existing evidence and their expert opinion concerning anaesthetic management in six specific groups of myopathies and neuromuscular junction disorders. The consensus statement was prepared according to the AGREE II (Appraisal of Guidelines for Research & Evaluation) reporting checklist. The level of evidence has been adapted according to the SIGN (Scottish Intercollegiate Guidelines Network) grading system. The final consensus statement was subjected to a modified Delphi process.RESULTS: A set of general recommendations valid for the anaesthetic management of patients with neuromuscular disorders in general have been formulated. Specific recommendations were formulated for (i) neuromuscular junction disorders, (ii) muscle channelopathies (nondystrophic myotonia and periodic paralysis), (iii) myotonic dystrophy (types 1 and 2), (iv) muscular dystrophies, (v) congenital myopathies and congenital dystrophies, and (vi) mitochondrial and metabolic myopathies.CONCLUSIONS: This ENMC consensus statement summarizes the most important considerations for planning and performing anaesthesia in patients with neuromuscular disorders.

AB - BACKGROUND AND PURPOSE: Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these patients. Here, we present the European Neuromuscular Centre (ENMC) consensus statement on anaesthesia in patients with neuromuscular disorders as formulated during the 259th ENMC Workshop on Anaesthesia in Neuromuscular Disorders.METHODS: International experts in the field of (paediatric) anaesthesia, neurology, and genetics were invited to participate in the ENMC workshop. A literature search was conducted in PubMed and Embase, the main findings of which were disseminated to the participants and presented during the workshop. Depending on specific expertise, participants presented the existing evidence and their expert opinion concerning anaesthetic management in six specific groups of myopathies and neuromuscular junction disorders. The consensus statement was prepared according to the AGREE II (Appraisal of Guidelines for Research & Evaluation) reporting checklist. The level of evidence has been adapted according to the SIGN (Scottish Intercollegiate Guidelines Network) grading system. The final consensus statement was subjected to a modified Delphi process.RESULTS: A set of general recommendations valid for the anaesthetic management of patients with neuromuscular disorders in general have been formulated. Specific recommendations were formulated for (i) neuromuscular junction disorders, (ii) muscle channelopathies (nondystrophic myotonia and periodic paralysis), (iii) myotonic dystrophy (types 1 and 2), (iv) muscular dystrophies, (v) congenital myopathies and congenital dystrophies, and (vi) mitochondrial and metabolic myopathies.CONCLUSIONS: This ENMC consensus statement summarizes the most important considerations for planning and performing anaesthesia in patients with neuromuscular disorders.

UR - http://www.scopus.com/inward/record.url?scp=85138046768&partnerID=8YFLogxK

U2 - 10.1111/ene.15526

DO - 10.1111/ene.15526

M3 - Article

C2 - 35971866

SN - 1351-5101

VL - 29

SP - 3486

EP - 3507

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 12

ER -