Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Julian Enrico Tillmann; Karen Ashwood; Michael Absoud; Sven Bolte; Frédérique Bonnet-Brilhault; Jan Buitelaar; Sara Calderoni; Rosa Calvo; Ricardo Canal-bedia; Roberto Canitano; Annelies de Bildt; Marie Gomot; Pieter J. Hoekstra; Anett Kaale; Helen McConachie; Declan G Murphy; Antonio Narzisi; Iris Oosterling; Milica Pejovic-Milovancevic; Antonio M. Persico; Olga Puig; Herbert Roeyers; Nanda Rommelse; Roberto Sacco; Valeria Scandurra; Andrew Stanfield; Eric Zander; Tony Charman

doi:10.1007/s10803-018-3510-4

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Julian Enrico Tillmann, Karen Ashwood, Michael Absoud, Sven Bolte, Frédérique Bonnet-Brilhault, Jan Buitelaar, Sara Calderoni, Rosa Calvo, Ricardo Canal-bedia, Roberto Canitano, Annelies de Bildt, Marie Gomot, Pieter J. Hoekstra, Anett Kaale, Helen McConachie, Declan G Murphy, Antonio Narzisi, Iris Oosterling, Milica Pejovic-Milovancevic, Antonio M. PersicoOlga Puig, Herbert Roeyers, Nanda Rommelse, Roberto Sacco, Valeria Scandurra, Andrew Stanfield, Eric Zander, Tony Charman

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Abstract

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

Original language	English
Journal	Journal of Autism and Developmental Disorders
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1007/s10803-018-3510-4
Publication status	Published - Jul 2018

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Tillmann, J. E., Ashwood, K., Absoud, M., Bolte, S., Bonnet-Brilhault, F., Buitelaar, J., Calderoni, S., Calvo, R., Canal-bedia, R., Canitano, R., de Bildt, A., Gomot, M., Hoekstra, P. J., Kaale, A., McConachie, H., Murphy, D. G., Narzisi, A., Oosterling, I., Pejovic-Milovancevic, M., ... Charman, T. (2018). Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-018-3510-4

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title = "Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder",

abstract = "Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.",

author = "Tillmann, {Julian Enrico} and Karen Ashwood and Michael Absoud and Sven Bolte and Fr{\'e}d{\'e}rique Bonnet-Brilhault and Jan Buitelaar and Sara Calderoni and Rosa Calvo and Ricardo Canal-bedia and Roberto Canitano and {de Bildt}, Annelies and Marie Gomot and Hoekstra, {Pieter J.} and Anett Kaale and Helen McConachie and Murphy, {Declan G} and Antonio Narzisi and Iris Oosterling and Milica Pejovic-Milovancevic and Persico, {Antonio M.} and Olga Puig and Herbert Roeyers and Nanda Rommelse and Roberto Sacco and Valeria Scandurra and Andrew Stanfield and Eric Zander and Tony Charman",

year = "2018",

month = jul,

doi = "10.1007/s10803-018-3510-4",

language = "English",

journal = "Journal of Autism and Developmental Disorders",

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Tillmann, JE , Ashwood, K , Absoud, M, Bolte, S, Bonnet-Brilhault, F, Buitelaar, J, Calderoni, S, Calvo, R, Canal-bedia, R, Canitano, R, de Bildt, A, Gomot, M, Hoekstra, PJ, Kaale, A, McConachie, H, Murphy, DG, Narzisi, A, Oosterling, I, Pejovic-Milovancevic, M, Persico, AM, Puig, O, Roeyers, H, Rommelse, N, Sacco, R, Scandurra, V, Stanfield, A, Zander, E & Charman, T 2018, 'Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder', Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-018-3510-4

TY - JOUR

T1 - Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

AU - Tillmann, Julian Enrico

AU - Ashwood, Karen

AU - Absoud, Michael

AU - Bolte, Sven

AU - Bonnet-Brilhault, Frédérique

AU - Buitelaar, Jan

AU - Calderoni, Sara

AU - Calvo, Rosa

AU - Canal-bedia, Ricardo

AU - Canitano, Roberto

AU - de Bildt, Annelies

AU - Gomot, Marie

AU - Hoekstra, Pieter J.

AU - Kaale, Anett

AU - McConachie, Helen

AU - Murphy, Declan G

AU - Narzisi, Antonio

AU - Oosterling, Iris

AU - Pejovic-Milovancevic, Milica

AU - Persico, Antonio M.

AU - Puig, Olga

AU - Roeyers, Herbert

AU - Rommelse, Nanda

AU - Sacco, Roberto

AU - Scandurra, Valeria

AU - Stanfield, Andrew

AU - Zander, Eric

AU - Charman, Tony

PY - 2018/7

Y1 - 2018/7

N2 - Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

AB - Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

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U2 - 10.1007/s10803-018-3510-4

DO - 10.1007/s10803-018-3510-4

M3 - Article

SN - 0162-3257

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

ER -

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

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