Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study

Nikolaos Kyriakakis; Marilena Giannoudi; Satish S  Kumar; Khyatisha  Seejore; Georgios K Dimitriadis; Harpal S  Randeva; Adam W Glaser; Michelle  Kwok-Williams; Georgina Gerrard Ba; Carmel  Loughrey; Ahmed  Al-Qaissi; Ramzi A Ajjan; Julie  Lynch; Robert D  Murray

Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study

Nikolaos Kyriakakis, Marilena Giannoudi, Satish S Kumar, Khyatisha Seejore, Georgios K Dimitriadis, Harpal S Randeva, Adam W Glaser, Michelle Kwok-Williams, Georgina Gerrard Ba, Carmel Loughrey, Ahmed Al-Qaissi, Ramzi A Ajjan, Julie Lynch, Robert D Murray

Diabetes

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Survivors of childhood brain tumours (SCBT) and teenage and young adult cancer survivors have an adverse cardiovascular risk profile, which translates into an increased vascular mortality. Data on cardiovascular risk profile in SCBT are limited and furthermore there are no data in adult-onset brain tumours.

Patients and methods: Fasting lipids, glucose, insulin, 24-hour blood pressure, and body composition were measured in 36 brain tumours survivors [20 adult-onset (AO); 16 childhood-onset (CO)] and 36 age- and gender-matched controls.

Results: Compared with controls, patients had elevated total cholesterol (5.3±1.1 Vs. 4.6±1.0mmol/l, p=0.007), LDL-C (3.1±0.8 Vs. 2.7±0.9mmol/l, p=0.011), insulin (13.4±13.1 Vs. 7.6±3.3miu/l, p=0.014) and increased insulin resistance (HOMA-IR 2.90±2.84 Vs. 1.66±0.73, p=0.016). Patients showed adverse body composition, with increased total body fat mass (FM) (24.0±12.2 Vs. 15.7±6.6kg, p
Conclusion: The phenotype of both CO and AO brain tumour survivors is characterized by an adverse metabolic profile and body composition, putatively placing long-term survivors at increased risk of vascular morbidity and mortality.

Original language	English
Journal	Endocrine Connections
Publication status	Accepted/In press - 28 May 2023

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Kyriakakis, N., Giannoudi, M., Kumar, S. S., Seejore, K., Dimitriadis, G. K., Randeva, H. S., Glaser, A. W., Kwok-Williams, M., Gerrard Ba, G., Loughrey, C., Al-Qaissi, A., Ajjan, R. A., Lynch, J., & Murray, R. D. (Accepted/In press). Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study. Endocrine Connections.

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title = "Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study",

abstract = "Background: Survivors of childhood brain tumours (SCBT) and teenage and young adult cancer survivors have an adverse cardiovascular risk profile, which translates into an increased vascular mortality. Data on cardiovascular risk profile in SCBT are limited and furthermore there are no data in adult-onset brain tumours.Patients and methods: Fasting lipids, glucose, insulin, 24-hour blood pressure, and body composition were measured in 36 brain tumours survivors [20 adult-onset (AO); 16 childhood-onset (CO)] and 36 age- and gender-matched controls.Results: Compared with controls, patients had elevated total cholesterol (5.3±1.1 Vs. 4.6±1.0mmol/l, p=0.007), LDL-C (3.1±0.8 Vs. 2.7±0.9mmol/l, p=0.011), insulin (13.4±13.1 Vs. 7.6±3.3miu/l, p=0.014) and increased insulin resistance (HOMA-IR 2.90±2.84 Vs. 1.66±0.73, p=0.016). Patients showed adverse body composition, with increased total body fat mass (FM) (24.0±12.2 Vs. 15.7±6.6kg, pConclusion: The phenotype of both CO and AO brain tumour survivors is characterized by an adverse metabolic profile and body composition, putatively placing long-term survivors at increased risk of vascular morbidity and mortality.",

author = "Nikolaos Kyriakakis and Marilena Giannoudi and Kumar, {Satish S} and Khyatisha Seejore and Dimitriadis, {Georgios K} and Randeva, {Harpal S} and Glaser, {Adam W} and Michelle Kwok-Williams and {Gerrard Ba}, Georgina and Carmel Loughrey and Ahmed Al-Qaissi and Ajjan, {Ramzi A} and Julie Lynch and Murray, {Robert D}",

year = "2023",

month = may,

day = "28",

language = "English",

journal = "Endocrine Connections",

issn = "2049-3614",

publisher = "BioScientifica Ltd.",

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TY - JOUR

T1 - Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study

AU - Kyriakakis, Nikolaos

AU - Giannoudi, Marilena

AU - Kumar, Satish S

AU - Seejore, Khyatisha

AU - Dimitriadis, Georgios K

AU - Randeva, Harpal S

AU - Glaser, Adam W

AU - Kwok-Williams, Michelle

AU - Gerrard Ba, Georgina

AU - Loughrey, Carmel

AU - Al-Qaissi, Ahmed

AU - Ajjan, Ramzi A

AU - Lynch, Julie

AU - Murray, Robert D

PY - 2023/5/28

Y1 - 2023/5/28

N2 - Background: Survivors of childhood brain tumours (SCBT) and teenage and young adult cancer survivors have an adverse cardiovascular risk profile, which translates into an increased vascular mortality. Data on cardiovascular risk profile in SCBT are limited and furthermore there are no data in adult-onset brain tumours.Patients and methods: Fasting lipids, glucose, insulin, 24-hour blood pressure, and body composition were measured in 36 brain tumours survivors [20 adult-onset (AO); 16 childhood-onset (CO)] and 36 age- and gender-matched controls.Results: Compared with controls, patients had elevated total cholesterol (5.3±1.1 Vs. 4.6±1.0mmol/l, p=0.007), LDL-C (3.1±0.8 Vs. 2.7±0.9mmol/l, p=0.011), insulin (13.4±13.1 Vs. 7.6±3.3miu/l, p=0.014) and increased insulin resistance (HOMA-IR 2.90±2.84 Vs. 1.66±0.73, p=0.016). Patients showed adverse body composition, with increased total body fat mass (FM) (24.0±12.2 Vs. 15.7±6.6kg, pConclusion: The phenotype of both CO and AO brain tumour survivors is characterized by an adverse metabolic profile and body composition, putatively placing long-term survivors at increased risk of vascular morbidity and mortality.

AB - Background: Survivors of childhood brain tumours (SCBT) and teenage and young adult cancer survivors have an adverse cardiovascular risk profile, which translates into an increased vascular mortality. Data on cardiovascular risk profile in SCBT are limited and furthermore there are no data in adult-onset brain tumours.Patients and methods: Fasting lipids, glucose, insulin, 24-hour blood pressure, and body composition were measured in 36 brain tumours survivors [20 adult-onset (AO); 16 childhood-onset (CO)] and 36 age- and gender-matched controls.Results: Compared with controls, patients had elevated total cholesterol (5.3±1.1 Vs. 4.6±1.0mmol/l, p=0.007), LDL-C (3.1±0.8 Vs. 2.7±0.9mmol/l, p=0.011), insulin (13.4±13.1 Vs. 7.6±3.3miu/l, p=0.014) and increased insulin resistance (HOMA-IR 2.90±2.84 Vs. 1.66±0.73, p=0.016). Patients showed adverse body composition, with increased total body fat mass (FM) (24.0±12.2 Vs. 15.7±6.6kg, pConclusion: The phenotype of both CO and AO brain tumour survivors is characterized by an adverse metabolic profile and body composition, putatively placing long-term survivors at increased risk of vascular morbidity and mortality.

M3 - Article

SN - 2049-3614

JO - Endocrine Connections

JF - Endocrine Connections

ER -

Evaluation of cardiovascular risk factors in long-term survivors of adult and childhood-onset brain tumours - a pilot study

Abstract

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