King's College London

Research portal

Evaluation of nocturnal hypokinesia in Parkinson’s disease using a novel patient/proxy questionnaire and correlations with objective monitoring

Research output: Contribution to journalArticle

Roongroj Bhidayasiri, Onanong Phokaewvarangkul, Jirada Sringean, Pablo Martinez-Martin, Chanawat Anan, Nitinan Kantachadvanich, K. Ray Chaudhuri, Nobutaka Hattori

Original languageEnglish
JournalParkinsonism & Related Disorders
Early online date21 Sep 2018
Publication statusE-pub ahead of print - 21 Sep 2018

King's Authors


Background Nocturnal hypokinesia is a decreased ability to perform sufficient axial rotation and/or trunk flexion to turn in or get out of bed. Currently, there are no validated questionnaires specifically to assess nocturnal hypokinesia in PD patients. Objective To develop and validate a questionnaire to assess PD patients’ problems associated with turning or getting out of bed. Methods The nocturnal hypokinesia questionnaire (NHQ) consists of 10 items, completed independently by patients and their caregivers. For validation, 76 patient-caregiver pairs completed the questionnaire and validity, agreement levels, and internal consistency assessed. In addition, 76 healthy couples served as controls. The NHQ and Modified Parkinson's Disease Sleep Scale (PDSS-2) were compared and 25 random patients-caregiver pairs were also assessed with objective night-time monitoring. Results Patient and caregiver scores showed a high level of agreement (Intra-class correlation: 0.84) with high internal consistency (KR-20 coefficient of 0.73 for patients and 0.69 for caregivers). No significant difference between the mean total NHQ scores as rated by patients and caregivers was observed. Mean NHQ scores from patients and caregivers were significantly higher than healthy controls (p 

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454