Evaluation of the influence of ayurvedic formulation (Ayushman-15) on psychopathology, heart rate variability and stress hormonal level in major depression (Vishada)

Ramakrishna K Kishore, Hulegar A. Abhishekh, Kaviraja Udupa, Jagadisha Thirthalli, Gandhidas S Lavekar, Bangalore N Gangadhar, Trichur R Raju, Talakad N Sathyaprabha

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15 Citations (Scopus)

Abstract

INTRODUCTION: Ayurveda (Indian-complimentary and alternative medicine) is still most sought after in India and has promising potential in management of Vishada [major depressive disorder (MDD)]. But, systematic research is lacking. In this study we evaluated of influence of ayurvedic treatment (Panchakarma and Ayushman-15) on psychopathology, heart rate variability (HRV) and endocrinal parameters in patients with major depression.

METHODS: 81 drug naive patients diagnosed as Vishada by ayurvedic physician and MDD according to DSM IV-TR were given ayurvedic Virechana module (therapeutic purgation) and were randomized into two groups. Patients in group A (n=41) received Ayushman-15A while group B (n=40) received Ayushman-15B for two months and Shirodhara (forehead-oil pouring therapy). Patients were assessed with Hamilton Depression Rating Scale (HDRS), Montgomery Asberg Depression Rating Scale (MADRS), Heart Rate Variability (HRV). Cortisol and adrenocorticotropic hormone (ACTH) were estimated at baseline and after ayurvedic therapy. HRV and endocrinal parameters were compared with age and gender matched healthy volunteers.

RESULTS: HRV parameters showed significant sympathetic dominance in patients compared to healthy volunteers. Two months of ayurvedic treatment significantly decreased psychopathology, showed increase in vagal tone, decrease in sympathetic tone and reduced cortisol levels. However, there was no significant difference between groups receiving Ayushman A and B.

CONCLUSION: This study provides evidence for antidepressant, cardiac (HRV) and beneficial neuroendocrine modulatory influence of Ayurveda therapy in patients of Vishada (MDD). Further studies are needed to confirm these findings. Greater insight into the neurobiology behind this therapy might provide valuable information about newer drug target.

Original languageEnglish
Pages (from-to)100-7
Number of pages8
JournalAsian journal of psychiatry
Volume12
Early online date26 Aug 2014
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Adrenocorticotropic Hormone
  • Adult
  • Antidepressive Agents
  • Depressive Disorder, Major
  • Female
  • Heart Rate
  • Humans
  • Hydrocortisone
  • Male
  • Medicine, Ayurvedic
  • Plant Extracts
  • Single-Blind Method
  • Treatment Outcome
  • Young Adult

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