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Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD

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Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD. / Vainieri, Isabella; Michelini, Giorgia; Adamo, Nicoletta et al.

In: Psychological Medicine, 27.05.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Vainieri, I, Michelini, G, Adamo, N, Cheung, C, Asherson, P & Kuntsi, J 2020, 'Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD', Psychological Medicine. <https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6E64DC8F7F786C9D4424A9C4A7F45666/S0033291720002056a.pdf/eventrelated_brainoscillatory_and_exgaussian_markers_of_remission_and_persistence_of_adhd.pdf>

APA

Vainieri, I., Michelini, G., Adamo, N., Cheung, C., Asherson, P., & Kuntsi, J. (Accepted/In press). Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD. Psychological Medicine. https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6E64DC8F7F786C9D4424A9C4A7F45666/S0033291720002056a.pdf/eventrelated_brainoscillatory_and_exgaussian_markers_of_remission_and_persistence_of_adhd.pdf

Vancouver

Vainieri I, Michelini G, Adamo N, Cheung C, Asherson P, Kuntsi J. Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD. Psychological Medicine. 2020 May 27.

Author

Vainieri, Isabella ; Michelini, Giorgia ; Adamo, Nicoletta et al. / Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD. In: Psychological Medicine. 2020.

Bibtex Download

@article{571913c717a64163918b6b7039d4e45a,
title = "Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD",
abstract = "Background: Attention-deficit/hyperactivity disorder (ADHD) often persists into adolescence and adulthood, but the processes underlying persistence and remission remain poorly understood. We previously found that reaction time variability and event-related potentials of preparation-vigilance processes were impaired in ADHD persisters and represented markers of remission, as ADHD remitters were indistinguishable from controls but differed from persisters. Here, we aimed to further clarify the nature of the cognitive-neurophysiological impairments in ADHD and of markers of remission by examining finer-grained ex-Gaussian reaction-time distribution and electroencephalographic (EEG) brain-oscillatory measures in ADHD persisters, remitters and controls. Methods: 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched controls were compared on ex-Gaussian (mu, sigma, tau) indices and time-frequency EEG measures of power and phase consistency from a reaction-time task with slow-unrewarded baseline and fast-incentive conditions (“Fast task”). Results: Compared to controls, ADHD persisters showed significantly greater mu, sigma, tau, and lower theta power and phase consistency across conditions. Relative to ADHD persisters, remitters showed significantly lower tau and theta power and phase consistency across conditions, as well as lower mu in the fast-incentive condition, with no difference in the baseline condition. Remitters did not significantly differ from controls on any measure.Conclusions: We found widespread impairments in ADHD persisters in reaction-time distribution and brain-oscillatory measures. Event-related theta power, theta phase consistency and tau across conditions, as well as mu in the more engaging fast-incentive condition, emerged as novel markers of ADHD remission, potentially representing compensatory mechanisms in individuals with remitted ADHD.",
author = "Isabella Vainieri and Giorgia Michelini and Nicoletta Adamo and Celeste Cheung and Philip Asherson and Jonna Kuntsi",
year = "2020",
month = may,
day = "27",
language = "English",
journal = "Psychological medicine",
issn = "0033-2917",
publisher = "Cambridge University Press (CUP)",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD

AU - Vainieri, Isabella

AU - Michelini, Giorgia

AU - Adamo, Nicoletta

AU - Cheung, Celeste

AU - Asherson, Philip

AU - Kuntsi, Jonna

PY - 2020/5/27

Y1 - 2020/5/27

N2 - Background: Attention-deficit/hyperactivity disorder (ADHD) often persists into adolescence and adulthood, but the processes underlying persistence and remission remain poorly understood. We previously found that reaction time variability and event-related potentials of preparation-vigilance processes were impaired in ADHD persisters and represented markers of remission, as ADHD remitters were indistinguishable from controls but differed from persisters. Here, we aimed to further clarify the nature of the cognitive-neurophysiological impairments in ADHD and of markers of remission by examining finer-grained ex-Gaussian reaction-time distribution and electroencephalographic (EEG) brain-oscillatory measures in ADHD persisters, remitters and controls. Methods: 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched controls were compared on ex-Gaussian (mu, sigma, tau) indices and time-frequency EEG measures of power and phase consistency from a reaction-time task with slow-unrewarded baseline and fast-incentive conditions (“Fast task”). Results: Compared to controls, ADHD persisters showed significantly greater mu, sigma, tau, and lower theta power and phase consistency across conditions. Relative to ADHD persisters, remitters showed significantly lower tau and theta power and phase consistency across conditions, as well as lower mu in the fast-incentive condition, with no difference in the baseline condition. Remitters did not significantly differ from controls on any measure.Conclusions: We found widespread impairments in ADHD persisters in reaction-time distribution and brain-oscillatory measures. Event-related theta power, theta phase consistency and tau across conditions, as well as mu in the more engaging fast-incentive condition, emerged as novel markers of ADHD remission, potentially representing compensatory mechanisms in individuals with remitted ADHD.

AB - Background: Attention-deficit/hyperactivity disorder (ADHD) often persists into adolescence and adulthood, but the processes underlying persistence and remission remain poorly understood. We previously found that reaction time variability and event-related potentials of preparation-vigilance processes were impaired in ADHD persisters and represented markers of remission, as ADHD remitters were indistinguishable from controls but differed from persisters. Here, we aimed to further clarify the nature of the cognitive-neurophysiological impairments in ADHD and of markers of remission by examining finer-grained ex-Gaussian reaction-time distribution and electroencephalographic (EEG) brain-oscillatory measures in ADHD persisters, remitters and controls. Methods: 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched controls were compared on ex-Gaussian (mu, sigma, tau) indices and time-frequency EEG measures of power and phase consistency from a reaction-time task with slow-unrewarded baseline and fast-incentive conditions (“Fast task”). Results: Compared to controls, ADHD persisters showed significantly greater mu, sigma, tau, and lower theta power and phase consistency across conditions. Relative to ADHD persisters, remitters showed significantly lower tau and theta power and phase consistency across conditions, as well as lower mu in the fast-incentive condition, with no difference in the baseline condition. Remitters did not significantly differ from controls on any measure.Conclusions: We found widespread impairments in ADHD persisters in reaction-time distribution and brain-oscillatory measures. Event-related theta power, theta phase consistency and tau across conditions, as well as mu in the more engaging fast-incentive condition, emerged as novel markers of ADHD remission, potentially representing compensatory mechanisms in individuals with remitted ADHD.

M3 - Article

JO - Psychological medicine

JF - Psychological medicine

SN - 0033-2917

ER -

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