TY - JOUR
T1 - Evidence for a decrease in cardiovascular risk factors following recombinant growth hormone administration in abstinent anabolic-androgenic steroid users
AU - Graham, M R
AU - Baker, J S
AU - Evans, P
AU - Kicman, A
AU - Cowan, D
AU - Hullin, D
AU - Davies, B
PY - 2007/6
Y1 - 2007/6
N2 - Objectives: To determine whether six days recombinant human growth hormone (rhGH) in an abstinent anabolic-androgenic steroid (AAS) group had any cardiovascular and biochemical effects compared with a control group. Methods: Male subjects (n = 48) were randomly divided, using a single blind procedure into two groups: (1) control group (C) n = 24, mean +/- SD, age 32 +/- 11 years; height 1.8 +/- 0.06 m; (2) rhGH using group (0.058 IU kg(-1) day(-1)) (GH) n = 24, mean +/- SD. age 32 +/- 9 years; height 1.8 +/- 0.07 m. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), peak oxygen uptake (VO2 peak) and biochemical indices were investigated. Results: Body mass index, fat-free mass index and VO2 peak significantly increased while body fat significantly decreased within GH (all P <0.017). Insulin like growth factor-I significantly increased within GH (P <0.017) and compared with C (P <0.05). Serum sodium significantly increased (P <0.017) and serum homocysteine, high sensitivity C-reactive protein, thyroid stimulating hormone and tetra-iodothyronine (T-4), significantly decreased within GH (all P
AB - Objectives: To determine whether six days recombinant human growth hormone (rhGH) in an abstinent anabolic-androgenic steroid (AAS) group had any cardiovascular and biochemical effects compared with a control group. Methods: Male subjects (n = 48) were randomly divided, using a single blind procedure into two groups: (1) control group (C) n = 24, mean +/- SD, age 32 +/- 11 years; height 1.8 +/- 0.06 m; (2) rhGH using group (0.058 IU kg(-1) day(-1)) (GH) n = 24, mean +/- SD. age 32 +/- 9 years; height 1.8 +/- 0.07 m. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), peak oxygen uptake (VO2 peak) and biochemical indices were investigated. Results: Body mass index, fat-free mass index and VO2 peak significantly increased while body fat significantly decreased within GH (all P <0.017). Insulin like growth factor-I significantly increased within GH (P <0.017) and compared with C (P <0.05). Serum sodium significantly increased (P <0.017) and serum homocysteine, high sensitivity C-reactive protein, thyroid stimulating hormone and tetra-iodothyronine (T-4), significantly decreased within GH (all P
U2 - 10.1016/j.ghir.2007.01.010
DO - 10.1016/j.ghir.2007.01.010
M3 - Article
VL - 17
SP - 201
EP - 209
JO - GROWTH HORMONE AND IGF RESEARCH
JF - GROWTH HORMONE AND IGF RESEARCH
IS - 3
ER -
