Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

A Banvolgyi, L Palinkas, T Berki, N Clark, A D Grant, Z Helyes, G Pozsgai, J Szolcsanyi, S D Brain, E Pinter

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin I receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. (C) 2005 Elsevier B.V. All rights reserved
Original languageEnglish
Pages (from-to)86 - 96
Number of pages11
JournalJournal of Neuroimmunology
Volume169
Issue number1-2
DOIs
Publication statusPublished - Dec 2005

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