Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

TY - JOUR

T1 - Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

AU - Banvolgyi, A

AU - Palinkas, L

AU - Berki, T

AU - Clark, N

AU - Grant, A D

AU - Helyes, Z

AU - Pozsgai, G

AU - Szolcsanyi, J

AU - Brain, S D

AU - Pinter, E

PY - 2005/12

Y1 - 2005/12

N2 - The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin I receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. (C) 2005 Elsevier B.V. All rights reserved

AB - The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin I receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. (C) 2005 Elsevier B.V. All rights reserved

U2 - 10.1016/j.jneuroim.2005.08.012

DO - 10.1016/j.jneuroim.2005.08.012

M3 - Article

VL - 169

SP - 86

EP - 96

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -