Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear

A D Grant, N P Gerard, S D Brain

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

1 The aims of this study were to develop a technique to measure blood flow in the mouse car and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. 2 The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK1 receptor knockout mice (-/-). Blood flow was assessed by laser Doppler flowmetry and oedema formation by I-125-albumin accumulation. 3 Capsaicin induced significant increases in blood flow (0.2-200 mug in 20 mul) and oedema (2-200 mug in 20 mul). The oedema response was absent in NK1 -/- mice and NK1 +/+ mice treated with the selective NK1 receptor antagonist SR140333 (480 nmol kg(-1)) as expected. Furthermore, the capsaicin-evoked increase in blood flow was significantly potentiated in the knockout mice (203% of wild-type response, P
Original languageEnglish
Pages (from-to)356 - 362
Number of pages7
JournalBritish Journal of Pharmacology
Volume135
Issue number2
DOIs
Publication statusPublished - 2002

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