Evidence of higher intramyocellular fat among normal and overweight Indians with prediabetes

S Sucharita, R Pranathi, M Correa, P Keerthana, L. J. Ramesh, G Bantwal, H. M. Venkatappa, K. P. Mahadev, T Thomas, R. J. Bosch, S. D. R. Harridge, A. V. Kurpad

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

BACKGROUND The rise in prevalence rates of Type 2 Diabetes among Indians is well recognized. The research focus has been primarily to understand the changes in insulin sensitivity and beta cell dysfunction among Indians with Type 2 Diabetes. However, no data are available on the role of peripheral tissue, in particular intramyocellular lipid (IMCL) content and its impact on glucose homeostasis among Indians with prediabetes. METHODS 28 male subjects (20-40 year) were studied. 13 with prediabetes (BMI ranging from 25.4 ± 2.9 kg/m2) and 15 controls (BMI ranging from 24.6 ± 2.8 kg/m2) were recruited. Body composition by dual energy X-ray absorptiometry (DXA), insulin sensitivity, insulin secretion rates were derived using the minimal model of C-peptide secretion and kinetics rates and skeletal muscle strength of the lower limb (quadriceps) was assessed using Isokinetic dynamometry. From muscle biopsy samples of the vastus lateralis, IMCL fat content (Oil red O staining) was determined. RESULTS The prediabetes group were older compared to controls (P 
Original languageEnglish
Pages (from-to)1373-1381
Number of pages9
JournalEuropean Journal of Clinical Nutrition
Volume73
Issue number10
Early online date6 Feb 2019
DOIs
Publication statusPublished - Oct 2019

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