Abstract
Background & Aims
Patients with liver disease often show profound abnormalities in their haemostatic system. Studies using thrombin generation demonstrate rebalanced coagulation in patients with chronic liver disease. Our aim was to evaluate the haemostatic profile in patients with acute liver injury/failure (ALI/ALF) compared with healthy controls.
Methods
Thrombin generation was measured in the presence and absence of thrombomodulin (TM) to activate protein C (PC) with endogenous thrombin potential (ETP; the area under the thrombin generation curve) a key parameter. Routine coagulation assays were also performed.
Results
Thirty two patients with ALI/ALF and 40 controls were recruited. Patients had grossly abnormal coagulation profiles with decreased pro- and anticoagulant factors compared with controls (P
Conclusion
ALI/ALF patients have normal ETP in the presence of TM. This supports rebalanced coagulation mediated by acquired PC resistance because of the reduction in PC, Factor V and concomitant increase in Factor VIII.
| Original language | English |
|---|---|
| Pages (from-to) | 672-678 |
| Number of pages | 7 |
| Journal | LIVER INTERNATIONAL |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2014 |
Keywords
- thrombin generation
- coagulation
- acute liver failure
- acute liver injury
- ACTIVATED PROTEIN-C
- FACTOR-V
- COAGULOPATHY
- DISEASE
- HEMOSTASIS
- DISORDERS
- CIRRHOSIS
- PRESSURE
- CAPACITY
- PLASMA