Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Maya Ghoussaini; Juliet D. French; Kyriaki Michailidou; Silje Nord; Jonathan Beesley; Sander Canisus; Kristine M. Hillman; Susanne Kaufmann; Haran Sivakumaran; Mahdi Moradi Marjaneh; Jason S. Lee; Joe Dennis; Manjeet K. Bolla; Qin Wang; Ed Dicks; Roger L. Milne; John L. Hopper; Melissa C. Southey; Marjanka K. Schmidt; Annegien Broeks; Kenneth Muir; Artitaya Lophatananon; Peter A. Fasching; Matthias W. Beckmann; Olivia Fletcher; Nichola Johnson; Elinor J. Sawyer; Ian Tomlinson; Barbara Burwinkel; Frederik Marme; Pascal Guénel; Thérèse Truong; Stig E. Bojesen; Henrik Flyger; Javier Benitez; Anna González-Neira; M. Rosario Alonso; Guillermo Pita; Susan L. Neuhausen; Hoda Anton-Culver; Hermann Brenner; Volker Arndt; Alfons Meindl; Rita K. Schmutzler; Hiltrud Brauch; Ute Hamann; Daniel C. Tessier; Daniel Vincent; Heli Nevanlinna; Sofia Khan; Keitaro Matsuo; Hidemi Ito; Thilo Dörk; Natalia V. Bogdanova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli-Matti Kosma; Anna H. Wu; David Van Den Berg; Diether Lambrechts; Giuseppe Floris; Jenny Chang-Claude; Anja Rudolph; Paolo Radice; Monica Barile; Fergus J. Couch; Emily Hallberg; Graham G. Giles; Christopher A. Haiman; Loic Le Marchand; Mark S. Goldberg; Soo H. Teo; Cheng Har Yip; Anne-Lise Borresen-Dale; Wei Zheng; Qiuyin Cai; Robert Winqvist; Katri Pylkäs; Irene L. Andrulis; Peter Devilee; Rob A.E.M. Tollenaar; Montserrat García-Closas; Jonine Figueroa; Per Hall; Kamila Czene; Judith S. Brand; Hatef Darabi; Mikael Eriksson; Maartje J. Hooning; Linetta B. Koppert; Jingmei Li; Xiao-Ou Shu; Ying Zheng; Angela Cox; Simon S. Cross; Mitul Shah; Valerie Rhenius; Ji-Yeob Choi; Daehee Kang; Mikael Hartman; Kee Seng Chia; Maria Kabisch; Diana Torres; Craig Luccarini; Don M. Conroy; Anna Jakubowska; Jan Lubinski; Suleeporn Sangrajrang; Paul Brennan; Curtis Olswold; Susan Slager; Chen-Yang Shen; Ming-Feng Hou; Anthony Swerdlow; Minouk J. Schoemaker; Jacques Simard; Paul D.P. Pharoah; Vessela Kristensen; Georgia Chenevix-Trench; Douglas F. Easton; Alison M. Dunning; Stacey L. Edwards

doi:10.1016/j.ajhg.2016.07.017

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Maya Ghoussaini, Juliet D. French, Kyriaki Michailidou, Silje Nord, Jonathan Beesley, Sander Canisus, Kristine M. Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh, Jason S. Lee, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ed Dicks, Roger L. Milne, John L. Hopper, Melissa C. Southey, Marjanka K. Schmidt, Annegien BroeksKenneth Muir, Artitaya Lophatananon, Peter A. Fasching, Matthias W. Beckmann, Olivia Fletcher, Nichola Johnson, Elinor J. Sawyer, Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E. Bojesen, Henrik Flyger, Javier Benitez, Anna González-Neira, M. Rosario Alonso, Guillermo Pita, Susan L. Neuhausen, Hoda Anton-Culver, Hermann Brenner, Volker Arndt, Alfons Meindl, Rita K. Schmutzler, Hiltrud Brauch, Ute Hamann, Daniel C. Tessier, Daniel Vincent, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hidemi Ito, Thilo Dörk, Natalia V. Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, Anna H. Wu, David Van Den Berg, Diether Lambrechts, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Monica Barile, Fergus J. Couch, Emily Hallberg, Graham G. Giles, Christopher A. Haiman, Loic Le Marchand, Mark S. Goldberg, Soo H. Teo, Cheng Har Yip, Anne-Lise Borresen-Dale, Wei Zheng, Qiuyin Cai, Robert Winqvist, Katri Pylkäs, Irene L. Andrulis, Peter Devilee, Rob A.E.M. Tollenaar, Montserrat García-Closas, Jonine Figueroa, Per Hall, Kamila Czene, Judith S. Brand, Hatef Darabi, Mikael Eriksson, Maartje J. Hooning, Linetta B. Koppert, Jingmei Li, Xiao-Ou Shu, Ying Zheng, Angela Cox, Simon S. Cross, Mitul Shah, Valerie Rhenius, Ji-Yeob Choi, Daehee Kang, Mikael Hartman, Kee Seng Chia, Maria Kabisch, Diana Torres, Craig Luccarini, Don M. Conroy, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, Paul Brennan, Curtis Olswold, Susan Slager, Chen-Yang Shen, Ming-Feng Hou, Anthony Swerdlow, Minouk J. Schoemaker, Jacques Simard, Paul D.P. Pharoah, Vessela Kristensen, Georgia Chenevix-Trench, Douglas F. Easton, Alison M. Dunning, Stacey L. Edwards

King's College London

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Abstract

Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen receptor-positive (ER+) breast cancer (per-g allele OR ER+ = 1.15; 95% CI 1.13–1.18; p = 8.35 × 10−30). After adjustment for rs10941679, we detected signal 2, consisting of 38 SNPs more strongly associated with ER-negative (ER−) breast cancer (lead SNP rs6864776: per-a allele OR ER− = 1.10; 95% CI 1.05–1.14; p conditional = 1.44 × 10−12), and a single signal 3 SNP (rs200229088: per-t allele OR ER+ = 1.12; 95% CI 1.09–1.15; p conditional = 1.12 × 10−05). Expression quantitative trait locus analysis in normal breast tissues and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased expression of FGF10 and MRPS30. Functional assays demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF10 and MRPS30 promoter regions in breast cancer cell lines. FGF10 is an oncogene that binds to FGFR2 and is overexpressed in ∼10% of human breast cancers, whereas MRPS30 plays a key role in apoptosis. These data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis.

Original language	English
Journal	American Journal of Human Genetics
Early online date	15 Sept 2016
DOIs	https://doi.org/10.1016/j.ajhg.2016.07.017
Publication status	E-pub ahead of print - 15 Sept 2016

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Evidence that the 5p12_FRENCH_Accepted 16Jul2016_GOLD VoRFinal published version, 1.13 MBLicence: CC BY

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Ghoussaini, M., French, JD., Michailidou, K., Nord, S., Beesley, J., Canisus, S., Hillman, KM., Kaufmann, S., Sivakumaran, H., Moradi Marjaneh, M., Lee, JS., Dennis, J., Bolla, MK., Wang, Q., Dicks, E., Milne, RL., Hopper, JL., Southey, MC., Schmidt, MK., ... Edwards, SL. (2016). Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. American Journal of Human Genetics. Advance online publication. https://doi.org/10.1016/j.ajhg.2016.07.017

@article{bd6dca3e769c4253aaeebd655e54f78c,

title = "Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation",

abstract = "Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen receptor-positive (ER+) breast cancer (per-g allele OR ER+ = 1.15; 95% CI 1.13–1.18; p = 8.35 × 10−30). After adjustment for rs10941679, we detected signal 2, consisting of 38 SNPs more strongly associated with ER-negative (ER−) breast cancer (lead SNP rs6864776: per-a allele OR ER− = 1.10; 95% CI 1.05–1.14; p conditional = 1.44 × 10−12), and a single signal 3 SNP (rs200229088: per-t allele OR ER+ = 1.12; 95% CI 1.09–1.15; p conditional = 1.12 × 10−05). Expression quantitative trait locus analysis in normal breast tissues and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased expression of FGF10 and MRPS30. Functional assays demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF10 and MRPS30 promoter regions in breast cancer cell lines. FGF10 is an oncogene that binds to FGFR2 and is overexpressed in ∼10% of human breast cancers, whereas MRPS30 plays a key role in apoptosis. These data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis.",

author = "Maya Ghoussaini and Juliet D. French and Kyriaki Michailidou and Silje Nord and Jonathan Beesley and Sander Canisus and Kristine M. Hillman and Susanne Kaufmann and Haran Sivakumaran and Mahdi Moradi Marjaneh and Jason S. Lee and Joe Dennis and Manjeet K. Bolla and Qin Wang and Ed Dicks and Roger L. Milne and John L. Hopper and Melissa C. Southey and Marjanka K. Schmidt and Annegien Broeks and Kenneth Muir and Artitaya Lophatananon and Peter A. Fasching and Matthias W. Beckmann and Olivia Fletcher and Nichola Johnson and Elinor J. Sawyer and Ian Tomlinson and Barbara Burwinkel and Frederik Marme and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Stig E. Bojesen and Henrik Flyger and Javier Benitez and Anna Gonz{\'a}lez-Neira and M. Rosario Alonso and Guillermo Pita and Susan L. Neuhausen and Hoda Anton-Culver and Hermann Brenner and Volker Arndt and Alfons Meindl and Rita K. Schmutzler and Hiltrud Brauch and Ute Hamann and Daniel C. Tessier and Daniel Vincent and Heli Nevanlinna and Sofia Khan and Keitaro Matsuo and Hidemi Ito and Thilo D{\"o}rk and Natalia V. Bogdanova and Annika Lindblom and Sara Margolin and Arto Mannermaa and Veli-Matti Kosma and Anna H. Wu and David Van Den Berg and Diether Lambrechts and Giuseppe Floris and Jenny Chang-Claude and Anja Rudolph and Paolo Radice and Monica Barile and Fergus J. Couch and Emily Hallberg and Graham G. Giles and Christopher A. Haiman and Loic Le Marchand and Mark S. Goldberg and Soo H. Teo and Cheng Har Yip and Anne-Lise Borresen-Dale and Wei Zheng and Qiuyin Cai and Robert Winqvist and Katri Pylk{\"a}s and Irene L. Andrulis and Peter Devilee and Rob A.E.M. Tollenaar and Montserrat Garc{\'i}a-Closas and Jonine Figueroa and Per Hall and Kamila Czene and Judith S. Brand and Hatef Darabi and Mikael Eriksson and Maartje J. Hooning and Linetta B. Koppert and Jingmei Li and Xiao-Ou Shu and Ying Zheng and Angela Cox and Simon S. Cross and Mitul Shah and Valerie Rhenius and Ji-Yeob Choi and Daehee Kang and Mikael Hartman and Kee Seng Chia and Maria Kabisch and Diana Torres and Craig Luccarini and Don M. Conroy and Anna Jakubowska and Jan Lubinski and Suleeporn Sangrajrang and Paul Brennan and Curtis Olswold and Susan Slager and Chen-Yang Shen and Ming-Feng Hou and Anthony Swerdlow and Minouk J. Schoemaker and Jacques Simard and Paul D.P. Pharoah and Vessela Kristensen and Georgia Chenevix-Trench and Douglas F. Easton and Alison M. Dunning and Stacey L. Edwards",

year = "2016",

month = sep,

day = "15",

doi = "10.1016/j.ajhg.2016.07.017",

language = "English",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Elsevier",

}

Ghoussaini, M, French, JD, Michailidou, K, Nord, S, Beesley, J, Canisus, S, Hillman, KM, Kaufmann, S, Sivakumaran, H, Moradi Marjaneh, M, Lee, JS, Dennis, J, Bolla, MK, Wang, Q, Dicks, E, Milne, RL, Hopper, JL, Southey, MC, Schmidt, MK, Broeks, A, Muir, K, Lophatananon, A, Fasching, PA, Beckmann, MW, Fletcher, O, Johnson, N, Sawyer, EJ, Tomlinson, I, Burwinkel, B, Marme, F, Guénel, P, Truong, T, Bojesen, SE, Flyger, H, Benitez, J, González-Neira, A, Alonso, MR, Pita, G, Neuhausen, SL, Anton-Culver, H, Brenner, H, Arndt, V, Meindl, A, Schmutzler, RK, Brauch, H, Hamann, U, Tessier, DC, Vincent, D, Nevanlinna, H, Khan, S, Matsuo, K, Ito, H, Dörk, T, Bogdanova, NV, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, V-M, Wu, AH, Van Den Berg, D, Lambrechts, D, Floris, G, Chang-Claude, J, Rudolph, A, Radice, P, Barile, M, Couch, FJ, Hallberg, E, Giles, GG, Haiman, CA, Le Marchand, L, Goldberg, MS, Teo, SH, Yip, CH, Borresen-Dale, A-L, Zheng, W, Cai, Q, Winqvist, R, Pylkäs, K, Andrulis, IL, Devilee, P, Tollenaar, RAEM, García-Closas, M, Figueroa, J, Hall, P, Czene, K, Brand, JS, Darabi, H, Eriksson, M, Hooning, MJ, Koppert, LB, Li, J, Shu, X-O, Zheng, Y, Cox, A, Cross, SS, Shah, M, Rhenius, V, Choi, J-Y, Kang, D, Hartman, M, Chia, KS, Kabisch, M, Torres, D, Luccarini, C, Conroy, DM, Jakubowska, A, Lubinski, J, Sangrajrang, S, Brennan, P, Olswold, C, Slager, S, Shen, C-Y, Hou, M-F, Swerdlow, A, Schoemaker, MJ, Simard, J, Pharoah, PDP, Kristensen, V, Chenevix-Trench, G, Easton, DF, Dunning, AM & Edwards, SL 2016, 'Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation', American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2016.07.017

TY - JOUR

T1 - Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

AU - Ghoussaini, Maya

AU - French, Juliet D.

AU - Michailidou, Kyriaki

AU - Nord, Silje

AU - Beesley, Jonathan

AU - Canisus, Sander

AU - Hillman, Kristine M.

AU - Kaufmann, Susanne

AU - Sivakumaran, Haran

AU - Moradi Marjaneh, Mahdi

AU - Lee, Jason S.

AU - Dennis, Joe

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dicks, Ed

AU - Milne, Roger L.

AU - Hopper, John L.

AU - Southey, Melissa C.

AU - Schmidt, Marjanka K.

AU - Broeks, Annegien

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Fasching, Peter A.

AU - Beckmann, Matthias W.

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Sawyer, Elinor J.

AU - Tomlinson, Ian

AU - Burwinkel, Barbara

AU - Marme, Frederik

AU - Guénel, Pascal

AU - Truong, Thérèse

AU - Bojesen, Stig E.

AU - Flyger, Henrik

AU - Benitez, Javier

AU - González-Neira, Anna

AU - Alonso, M. Rosario

AU - Pita, Guillermo

AU - Neuhausen, Susan L.

AU - Anton-Culver, Hoda

AU - Brenner, Hermann

AU - Arndt, Volker

AU - Meindl, Alfons

AU - Schmutzler, Rita K.

AU - Brauch, Hiltrud

AU - Hamann, Ute

AU - Tessier, Daniel C.

AU - Vincent, Daniel

AU - Nevanlinna, Heli

AU - Khan, Sofia

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Dörk, Thilo

AU - Bogdanova, Natalia V.

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli-Matti

AU - Wu, Anna H.

AU - Van Den Berg, David

AU - Lambrechts, Diether

AU - Floris, Giuseppe

AU - Chang-Claude, Jenny

AU - Rudolph, Anja

AU - Radice, Paolo

AU - Barile, Monica

AU - Couch, Fergus J.

AU - Hallberg, Emily

AU - Giles, Graham G.

AU - Haiman, Christopher A.

AU - Le Marchand, Loic

AU - Goldberg, Mark S.

AU - Teo, Soo H.

AU - Yip, Cheng Har

AU - Borresen-Dale, Anne-Lise

AU - Zheng, Wei

AU - Cai, Qiuyin

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Andrulis, Irene L.

AU - Devilee, Peter

AU - Tollenaar, Rob A.E.M.

AU - García-Closas, Montserrat

AU - Figueroa, Jonine

AU - Hall, Per

AU - Czene, Kamila

AU - Brand, Judith S.

AU - Darabi, Hatef

AU - Eriksson, Mikael

AU - Hooning, Maartje J.

AU - Koppert, Linetta B.

AU - Li, Jingmei

AU - Shu, Xiao-Ou

AU - Zheng, Ying

AU - Cox, Angela

AU - Cross, Simon S.

AU - Shah, Mitul

AU - Rhenius, Valerie

AU - Choi, Ji-Yeob

AU - Kang, Daehee

AU - Hartman, Mikael

AU - Chia, Kee Seng

AU - Kabisch, Maria

AU - Torres, Diana

AU - Luccarini, Craig

AU - Conroy, Don M.

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Sangrajrang, Suleeporn

AU - Brennan, Paul

AU - Olswold, Curtis

AU - Slager, Susan

AU - Shen, Chen-Yang

AU - Hou, Ming-Feng

AU - Swerdlow, Anthony

AU - Schoemaker, Minouk J.

AU - Simard, Jacques

AU - Pharoah, Paul D.P.

AU - Kristensen, Vessela

AU - Chenevix-Trench, Georgia

AU - Easton, Douglas F.

AU - Dunning, Alison M.

AU - Edwards, Stacey L.

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen receptor-positive (ER+) breast cancer (per-g allele OR ER+ = 1.15; 95% CI 1.13–1.18; p = 8.35 × 10−30). After adjustment for rs10941679, we detected signal 2, consisting of 38 SNPs more strongly associated with ER-negative (ER−) breast cancer (lead SNP rs6864776: per-a allele OR ER− = 1.10; 95% CI 1.05–1.14; p conditional = 1.44 × 10−12), and a single signal 3 SNP (rs200229088: per-t allele OR ER+ = 1.12; 95% CI 1.09–1.15; p conditional = 1.12 × 10−05). Expression quantitative trait locus analysis in normal breast tissues and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased expression of FGF10 and MRPS30. Functional assays demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF10 and MRPS30 promoter regions in breast cancer cell lines. FGF10 is an oncogene that binds to FGFR2 and is overexpressed in ∼10% of human breast cancers, whereas MRPS30 plays a key role in apoptosis. These data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis.

AB - Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen receptor-positive (ER+) breast cancer (per-g allele OR ER+ = 1.15; 95% CI 1.13–1.18; p = 8.35 × 10−30). After adjustment for rs10941679, we detected signal 2, consisting of 38 SNPs more strongly associated with ER-negative (ER−) breast cancer (lead SNP rs6864776: per-a allele OR ER− = 1.10; 95% CI 1.05–1.14; p conditional = 1.44 × 10−12), and a single signal 3 SNP (rs200229088: per-t allele OR ER+ = 1.12; 95% CI 1.09–1.15; p conditional = 1.12 × 10−05). Expression quantitative trait locus analysis in normal breast tissues and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased expression of FGF10 and MRPS30. Functional assays demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF10 and MRPS30 promoter regions in breast cancer cell lines. FGF10 is an oncogene that binds to FGFR2 and is overexpressed in ∼10% of human breast cancers, whereas MRPS30 plays a key role in apoptosis. These data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis.

U2 - 10.1016/j.ajhg.2016.07.017

DO - 10.1016/j.ajhg.2016.07.017

M3 - Article

SN - 0002-9297

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

ER -

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

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