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Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Research output: Contribution to journalArticle

Anthony Cleare, C M Pariante, A H Young, I M Anderson, D Christmas, P J Cowen, C Dickens, I N Ferrier, J Geddes, S Gilbody, P M Haddad, C Katona, G Lewis, A Malizia, R H McAllister-Williams, P Ramchandani, Jan Scott, David Taylor, Rudolf Uher, members of the Consensus Meeting

Original languageEnglish
Pages (from-to)459-525
Number of pages67
JournalJournal of Psychopharmacology
Issue number5
Early online date12 May 2015
Publication statusPublished - 21 May 2015


King's Authors


A revision of the 2008 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken in order to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in September 2012. Key areas in treating depression were reviewed and the strength of evidence and clinical implications were considered. The guidelines were then revised after extensive feedback from participants and interested parties. A literature review is provided which identifies the quality of evidence upon which the recommendations are made. These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse and stopping treatment. Significant changes since the last guidelines were published in 2008 include the availability of new antidepressant treatment options, improved evidence supporting certain augmentation strategies (drug and non-drug), management of potential long-term side effects, updated guidance for prescribing in elderly and adolescent populations and updated guidance for optimal prescribing. Suggestions for future research priorities are also made.

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