Evolution of the Treatment Paradigm for Patients with Metastatic Castration-Resistant Prostate Cancer

Zafar Malik*, Heather Payne, Jawaher Ansari, Simon Chowdhury, Mohammad Butt, Alison Birtle, Santhanam Sundar, Chinnamani Vee Eswar, Simon Hughes, Amit Bahl

*Corresponding author for this work

    Research output: Contribution to journalLiterature reviewpeer-review

    7 Citations (Scopus)

    Abstract

    As recently as 2004, treatment options for men with metastatic castration-resistant prostate cancer (mCRPC) were limited, with docetaxel the only approved agent conferring a survival benefit. The therapeutic landscape is now very different, with several agents demonstrating prolonged survival since 2010. New agents for the treatment of mCRPC include sipuleucel-T, cabazitaxel, abiraterone acetate, enzalutamide and radium-223. All are now approved for use in this patient group, although the specific licensing terms vary between agents. In addition, denosumab may have utility in patients with bone metastases. A number of novel agents are also in development with promising initial results. However, because these treatment options have proliferated rapidly, there is currently a paucity of clinical evidence regarding their optimal sequencing. Selection of an appropriate treatment option should take into consideration disease characteristics, drug availability and patient choice. In summary, we discuss several new treatment options available for mCRPC and their integration into the current treatment paradigm.

    Original languageEnglish
    Pages (from-to)1041-1066
    Number of pages26
    JournalADVANCES IN THERAPY
    Volume30
    Issue number12
    DOIs
    Publication statusPublished - Dec 2013

    Keywords

    • Abiraterone acetate
    • Cabazitaxel
    • Enzalutamide
    • Radium-223
    • Metastatic castration-resistant prostate cancer
    • Oncology
    • Sipuleucel-T
    • Treatment sequencing
    • MITOXANTRONE PLUS PREDNISONE
    • ADVANCED SOLID TUMORS
    • ABIRATERONE ACETATE
    • PHASE-I
    • INCREASED SURVIVAL
    • DOCETAXEL
    • CHEMOTHERAPY
    • CABAZITAXEL
    • TRIAL
    • CYP17

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