Evolution of white matter damage in amyotrophic lateral sclerosis

Matt C. Gabel, Rebecca J. Broad, Alexandra L. Young, Sharon Abrahams, Mark Bastin, Ricarda A. L. Menke, Ammar Al-Chalabi, Laura H. Goldstein, Stella Tsermentseli, Daniel Alexander, Martin Turner, P. Nigel Leigh, Mara Cercignani

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
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Abstract

Objective: To characterize disease evolution in amyotrophic lateral sclerosis using an event-based model designed to extract temporal information from cross-sectional data. Conventional methods for understanding mechanisms of rapidly progressive neurodegenerative disorders are limited by the subjectivity inherent in the selection of a limited range of measurements, and the need to acquire longitudinal data. Methods: The event-based model characterizes a disease as a series of events, each comprising a significant change in subject state. The model was applied to data from 154 patients and 128 healthy controls selected from five independent diffusion MRI datasets acquired in four different imaging laboratories between 1999 and 2016. The biomarkers modeled were mean fractional anisotropy values of white matter tracts implicated in amyotrophic lateral sclerosis. The cerebral portion of the corticospinal tract was divided into three segments. Results: Application of the model to the pooled datasets revealed that the corticospinal tracts were involved before other white matter tracts. Distal corticospinal tract segments were involved earlier than more proximal (i.e., cephalad) segments. In addition, the model revealed early ordering of fractional anisotropy change in the corpus callosum and subsequently in long association fibers. Interpretation: These findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.

Original languageEnglish
Pages (from-to)722-732
Number of pages11
JournalAnnals of Clinical and Translational Neurology
Volume7
Issue number5
Early online date4 May 2020
DOIs
Publication statusPublished - 1 Jun 2020

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