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Evolution of white matter damage in amyotrophic lateral sclerosis

Research output: Contribution to journalArticle

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Evolution of white matter damage in amyotrophic lateral sclerosis. / Gabel, Matt; Broad, Rebecca; Young, Alexandra; Abrahams, Sharon; Bastin, Mark; Menke, Ricarda; Al-Chalabi, Ammar; Goldstein, Laura; Tsermentseli, Stella; Alexander, Daniel; Turner, Martin; Leigh, P. Nigel; Cercignani, Mara.

In: Annals of Clinical and Translational Neurology, Vol. 7, 01.06.2020.

Research output: Contribution to journalArticle

Harvard

Gabel, M, Broad, R, Young, A, Abrahams, S, Bastin, M, Menke, R, Al-Chalabi, A, Goldstein, L, Tsermentseli, S, Alexander, D, Turner, M, Leigh, PN & Cercignani, M 2020, 'Evolution of white matter damage in amyotrophic lateral sclerosis', Annals of Clinical and Translational Neurology, vol. 7.

APA

Gabel, M., Broad, R., Young, A., Abrahams, S., Bastin, M., Menke, R., ... Cercignani, M. (2020). Evolution of white matter damage in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology, 7.

Vancouver

Gabel M, Broad R, Young A, Abrahams S, Bastin M, Menke R et al. Evolution of white matter damage in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology. 2020 Jun 1;7.

Author

Gabel, Matt ; Broad, Rebecca ; Young, Alexandra ; Abrahams, Sharon ; Bastin, Mark ; Menke, Ricarda ; Al-Chalabi, Ammar ; Goldstein, Laura ; Tsermentseli, Stella ; Alexander, Daniel ; Turner, Martin ; Leigh, P. Nigel ; Cercignani, Mara. / Evolution of white matter damage in amyotrophic lateral sclerosis. In: Annals of Clinical and Translational Neurology. 2020 ; Vol. 7.

Bibtex Download

@article{18dd9d5cb3b045ef989a394bb298b1a0,
title = "Evolution of white matter damage in amyotrophic lateral sclerosis",
abstract = "ObjectiveTo characterize disease evolution in amyotrophic lateral sclerosis using an event-based model designed to extract temporal information from cross-sectional data. Conventional methods for understanding mechanisms of rapidly progressive neurodegenerative disorders are limited by the subjectivity inherent in the selection of a limited range of measurements, and the need to acquire longitudinal data. MethodsThe event-based model characterizes a disease as a series of events, each comprising a significant change in subject state. The model was applied to data from 154 patients and 128 healthy controls selected from five independent diffusion MRI data sets acquired in four different imaging laboratories between 1999 and 2016. The biomarkers modelled were mean fractional anisotropy values of white matter tracts implicated in amyotrophic lateral sclerosis. The cerebral portion of the corticospinal tracts was divided into 3 segments.ResultsApplication of the model to the pooled datasets revealed that the corticospinal tracts were involved before other white matter tracts. Distal corticospinal tract segments were involved earlier than more proximal (i.e. cephalad) segments. In addition, the model revealed early ordering of fractional anisotropy change in the corpus callosum and subsequently in long association fibers.InterpretationThese findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.",
author = "Matt Gabel and Rebecca Broad and Alexandra Young and Sharon Abrahams and Mark Bastin and Ricarda Menke and Ammar Al-Chalabi and Laura Goldstein and Stella Tsermentseli and Daniel Alexander and Martin Turner and Leigh, {P. Nigel} and Mara Cercignani",
year = "2020",
month = "6",
day = "1",
language = "English",
volume = "7",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Evolution of white matter damage in amyotrophic lateral sclerosis

AU - Gabel, Matt

AU - Broad, Rebecca

AU - Young, Alexandra

AU - Abrahams, Sharon

AU - Bastin, Mark

AU - Menke, Ricarda

AU - Al-Chalabi, Ammar

AU - Goldstein, Laura

AU - Tsermentseli, Stella

AU - Alexander, Daniel

AU - Turner, Martin

AU - Leigh, P. Nigel

AU - Cercignani, Mara

PY - 2020/6/1

Y1 - 2020/6/1

N2 - ObjectiveTo characterize disease evolution in amyotrophic lateral sclerosis using an event-based model designed to extract temporal information from cross-sectional data. Conventional methods for understanding mechanisms of rapidly progressive neurodegenerative disorders are limited by the subjectivity inherent in the selection of a limited range of measurements, and the need to acquire longitudinal data. MethodsThe event-based model characterizes a disease as a series of events, each comprising a significant change in subject state. The model was applied to data from 154 patients and 128 healthy controls selected from five independent diffusion MRI data sets acquired in four different imaging laboratories between 1999 and 2016. The biomarkers modelled were mean fractional anisotropy values of white matter tracts implicated in amyotrophic lateral sclerosis. The cerebral portion of the corticospinal tracts was divided into 3 segments.ResultsApplication of the model to the pooled datasets revealed that the corticospinal tracts were involved before other white matter tracts. Distal corticospinal tract segments were involved earlier than more proximal (i.e. cephalad) segments. In addition, the model revealed early ordering of fractional anisotropy change in the corpus callosum and subsequently in long association fibers.InterpretationThese findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.

AB - ObjectiveTo characterize disease evolution in amyotrophic lateral sclerosis using an event-based model designed to extract temporal information from cross-sectional data. Conventional methods for understanding mechanisms of rapidly progressive neurodegenerative disorders are limited by the subjectivity inherent in the selection of a limited range of measurements, and the need to acquire longitudinal data. MethodsThe event-based model characterizes a disease as a series of events, each comprising a significant change in subject state. The model was applied to data from 154 patients and 128 healthy controls selected from five independent diffusion MRI data sets acquired in four different imaging laboratories between 1999 and 2016. The biomarkers modelled were mean fractional anisotropy values of white matter tracts implicated in amyotrophic lateral sclerosis. The cerebral portion of the corticospinal tracts was divided into 3 segments.ResultsApplication of the model to the pooled datasets revealed that the corticospinal tracts were involved before other white matter tracts. Distal corticospinal tract segments were involved earlier than more proximal (i.e. cephalad) segments. In addition, the model revealed early ordering of fractional anisotropy change in the corpus callosum and subsequently in long association fibers.InterpretationThese findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.

M3 - Article

VL - 7

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

SN - 2328-9503

ER -

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