Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Evangelos Papanastasiou; Elias Mouchlianitis; Dan W. Joyce; Philip McGuire; Celia Boussebaa; Tobias Banaschewski; Arun L.W. Bokde; Christian Büchel; Erin Quinlan; Sylvane Desrivières; Herta Flor; Antoine Grigis; Hugh Garavan; Philip Spechler; Penny Gowland; Andreas Heinz; Bernd Ittermann; Marie Laure Paillère Martinot; Eric Artiges; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Sabina Millenet; Juliane H. Fröhner; Michael N. Smolka; Henrik Walter; Robert Whelan; Gunter Schumann; Sukhwinder S. Shergill

doi:10.1038/s41598-020-62026-7

Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Evangelos Papanastasiou, Elias Mouchlianitis, Dan W. Joyce, Philip McGuire, Celia Boussebaa, Tobias Banaschewski, Arun L.W. Bokde, Christian Büchel, Erin Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Philip Spechler, Penny Gowland, Andreas Heinz, Bernd Ittermann, Marie Laure Paillère Martinot, Eric Artiges, Frauke NeesDimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Sukhwinder S. Shergill

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.

Original language	English
Article number	5164
Number of pages	1
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-62026-7
Publication status	Published - 20 Mar 2020

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Papanastasiou, E., Mouchlianitis, E., Joyce, D. W., McGuire, P., Boussebaa, C., Banaschewski, T., Bokde, A. L. W., Büchel, C., Quinlan, E., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Spechler, P., Gowland, P., Heinz, A., Ittermann, B., Martinot, M. L. P., Artiges, E., ... Shergill, S. S. (2020). Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces. Scientific Reports, 10(1), Article 5164. https://doi.org/10.1038/s41598-020-62026-7

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title = "Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces",

abstract = "Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.",

author = "Evangelos Papanastasiou and Elias Mouchlianitis and Joyce, {Dan W.} and Philip McGuire and Celia Boussebaa and Tobias Banaschewski and Bokde, {Arun L.W.} and Christian B{\"u}chel and Erin Quinlan and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Philip Spechler and Penny Gowland and Andreas Heinz and Bernd Ittermann and Martinot, {Marie Laure Paill{\`e}re} and Eric Artiges and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Sabina Millenet and Fr{\"o}hner, {Juliane H.} and Smolka, {Michael N.} and Henrik Walter and Robert Whelan and Gunter Schumann and Shergill, {Sukhwinder S.}",

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Papanastasiou, E , Mouchlianitis, E , Joyce, DW , McGuire, P, Boussebaa, C, Banaschewski, T, Bokde, ALW, Büchel, C, Quinlan, E , Desrivières, S, Flor, H, Grigis, A, Garavan, H, Spechler, P, Gowland, P, Heinz, A, Ittermann, B, Martinot, MLP, Artiges, E, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Millenet, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G & Shergill, SS 2020, 'Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces', Scientific Reports, vol. 10, no. 1, 5164. https://doi.org/10.1038/s41598-020-62026-7

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T1 - Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

AU - Papanastasiou, Evangelos

AU - Mouchlianitis, Elias

AU - Joyce, Dan W.

AU - McGuire, Philip

AU - Boussebaa, Celia

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Büchel, Christian

AU - Quinlan, Erin

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Spechler, Philip

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Marie Laure Paillère

AU - Artiges, Eric

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Millenet, Sabina

AU - Fröhner, Juliane H.

AU - Smolka, Michael N.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Shergill, Sukhwinder S.

PY - 2020/3/20

Y1 - 2020/3/20

N2 - Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.

AB - Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.

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VL - 10

JO - Scientific Reports

JF - Scientific Reports

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Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

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