Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Christine Therese Ferrara*, Susan Michelle Geyer, Yuk-Fun Liu, Carmella Evans-Molina, Ingrid M. Libman, Rachel Besser, Dorothy J. Becker, Henry Rodriguez, Antoinette Moran, Stephen E. Gitelman, Maria J. Redondo, Type 1 Diabetes TrialNet Study Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)
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OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. 

RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex and age-specific ceBMI thresholds for greatest type 1 diabetes risk. 

RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. 

CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

Original languageEnglish
Pages (from-to)698-701
JournalDiabetes Care
Issue number5
Early online date20 Apr 2017
Publication statusPublished - 1 May 2017


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