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Executive functions and memory abilities in children with 22q11.2 deletion syndrome

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Executive functions and memory abilities in children with 22q11.2 deletion syndrome. / Campbell, Linda E.; Azuma, Rayna; Ambery, Fiona; Stevens, Angela; Smith, Anna; Morris, Robin G.; Murphy, Declan G. M.; Murphy, Kieran C.

In: Australian and New Zealand Journal of Psychiatry, Vol. 44, No. 4, 2010, p. 364 - 371.

Research output: Contribution to journalArticle

Harvard

Campbell, LE, Azuma, R, Ambery, F, Stevens, A, Smith, A, Morris, RG, Murphy, DGM & Murphy, KC 2010, 'Executive functions and memory abilities in children with 22q11.2 deletion syndrome', Australian and New Zealand Journal of Psychiatry, vol. 44, no. 4, pp. 364 - 371.

APA

Campbell, L. E., Azuma, R., Ambery, F., Stevens, A., Smith, A., Morris, R. G., ... Murphy, K. C. (2010). Executive functions and memory abilities in children with 22q11.2 deletion syndrome. Australian and New Zealand Journal of Psychiatry, 44(4), 364 - 371.

Vancouver

Campbell LE, Azuma R, Ambery F, Stevens A, Smith A, Morris RG et al. Executive functions and memory abilities in children with 22q11.2 deletion syndrome. Australian and New Zealand Journal of Psychiatry. 2010;44(4):364 - 371.

Author

Campbell, Linda E. ; Azuma, Rayna ; Ambery, Fiona ; Stevens, Angela ; Smith, Anna ; Morris, Robin G. ; Murphy, Declan G. M. ; Murphy, Kieran C. / Executive functions and memory abilities in children with 22q11.2 deletion syndrome. In: Australian and New Zealand Journal of Psychiatry. 2010 ; Vol. 44, No. 4. pp. 364 - 371.

Bibtex Download

@article{f489f3e88a56446d9566b6ffd46d834a,
title = "Executive functions and memory abilities in children with 22q11.2 deletion syndrome",
abstract = "Objective: Velo-cardio-facial syndrome or 22q11.2 deletion syndrome (22q11DS) is the most common known microdeletion syndrome. One of the genes in the deleted region is the catechol-O-methyltransferase (COMT) gene, which is thought to have significant effects on cognition through its influence on dopamine metabolism. The aim of the present study was to better characterize the cognitive phenotype in a large cohort children with 22q11DS compared with sibling controls and to investigate if the cognitive deficits in 22q11DS were modulated by COMT expression. Method: The memory, executive function and attentional abilities of children with 22q11DS (n - 50) compared to sibling controls (n - 31), were measured. Also, within children with 22q11DS, a preliminary exploration was carried out of the relationship between cognitive ability and COMT genotype. Results: Overall, the 22q11DS group had significantly reduced scores on tests of memory (especially in visual memory) and executive function (particularly in planning, working memory, and motor organization) compared with sibling controls. No association, however, was identified between COMT genotype and cognitive function. Conclusions: Although 22q11DS children have specific cognitive deficits, differences in COMT do not account for these findings.",
author = "Campbell, {Linda E.} and Rayna Azuma and Fiona Ambery and Angela Stevens and Anna Smith and Morris, {Robin G.} and Murphy, {Declan G. M.} and Murphy, {Kieran C.}",
year = "2010",
language = "English",
volume = "44",
pages = "364 -- 371",
journal = "The Australian and New Zealand journal of psychiatry",
issn = "0004-8674",
publisher = "SAGE Publications Ltd",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Executive functions and memory abilities in children with 22q11.2 deletion syndrome

AU - Campbell, Linda E.

AU - Azuma, Rayna

AU - Ambery, Fiona

AU - Stevens, Angela

AU - Smith, Anna

AU - Morris, Robin G.

AU - Murphy, Declan G. M.

AU - Murphy, Kieran C.

PY - 2010

Y1 - 2010

N2 - Objective: Velo-cardio-facial syndrome or 22q11.2 deletion syndrome (22q11DS) is the most common known microdeletion syndrome. One of the genes in the deleted region is the catechol-O-methyltransferase (COMT) gene, which is thought to have significant effects on cognition through its influence on dopamine metabolism. The aim of the present study was to better characterize the cognitive phenotype in a large cohort children with 22q11DS compared with sibling controls and to investigate if the cognitive deficits in 22q11DS were modulated by COMT expression. Method: The memory, executive function and attentional abilities of children with 22q11DS (n - 50) compared to sibling controls (n - 31), were measured. Also, within children with 22q11DS, a preliminary exploration was carried out of the relationship between cognitive ability and COMT genotype. Results: Overall, the 22q11DS group had significantly reduced scores on tests of memory (especially in visual memory) and executive function (particularly in planning, working memory, and motor organization) compared with sibling controls. No association, however, was identified between COMT genotype and cognitive function. Conclusions: Although 22q11DS children have specific cognitive deficits, differences in COMT do not account for these findings.

AB - Objective: Velo-cardio-facial syndrome or 22q11.2 deletion syndrome (22q11DS) is the most common known microdeletion syndrome. One of the genes in the deleted region is the catechol-O-methyltransferase (COMT) gene, which is thought to have significant effects on cognition through its influence on dopamine metabolism. The aim of the present study was to better characterize the cognitive phenotype in a large cohort children with 22q11DS compared with sibling controls and to investigate if the cognitive deficits in 22q11DS were modulated by COMT expression. Method: The memory, executive function and attentional abilities of children with 22q11DS (n - 50) compared to sibling controls (n - 31), were measured. Also, within children with 22q11DS, a preliminary exploration was carried out of the relationship between cognitive ability and COMT genotype. Results: Overall, the 22q11DS group had significantly reduced scores on tests of memory (especially in visual memory) and executive function (particularly in planning, working memory, and motor organization) compared with sibling controls. No association, however, was identified between COMT genotype and cognitive function. Conclusions: Although 22q11DS children have specific cognitive deficits, differences in COMT do not account for these findings.

M3 - Article

VL - 44

SP - 364

EP - 371

JO - The Australian and New Zealand journal of psychiatry

JF - The Australian and New Zealand journal of psychiatry

SN - 0004-8674

IS - 4

ER -

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