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Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function

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Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. / Mendham, Amy E.; Larsen, Steen; George, Cindy; Adams, Kevin; Hauksson, Jon; Olsson, Tommy; Fortuin-de Smidt, Melony C.; Nono Nankam, Pamela A.; Hakim, Olah; Goff, Louise M.; Pheiffer, Carmen; Goedecke, Julia H.

In: Scientific Reports, Vol. 10, No. 1, 3785, 01.12.2020.

Research output: Contribution to journalArticle

Harvard

Mendham, AE, Larsen, S, George, C, Adams, K, Hauksson, J, Olsson, T, Fortuin-de Smidt, MC, Nono Nankam, PA, Hakim, O, Goff, LM, Pheiffer, C & Goedecke, JH 2020, 'Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function', Scientific Reports, vol. 10, no. 1, 3785. https://doi.org/10.1038/s41598-020-60286-x

APA

Mendham, A. E., Larsen, S., George, C., Adams, K., Hauksson, J., Olsson, T., ... Goedecke, J. H. (2020). Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Scientific Reports, 10(1), [3785]. https://doi.org/10.1038/s41598-020-60286-x

Vancouver

Mendham AE, Larsen S, George C, Adams K, Hauksson J, Olsson T et al. Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Scientific Reports. 2020 Dec 1;10(1). 3785. https://doi.org/10.1038/s41598-020-60286-x

Author

Mendham, Amy E. ; Larsen, Steen ; George, Cindy ; Adams, Kevin ; Hauksson, Jon ; Olsson, Tommy ; Fortuin-de Smidt, Melony C. ; Nono Nankam, Pamela A. ; Hakim, Olah ; Goff, Louise M. ; Pheiffer, Carmen ; Goedecke, Julia H. / Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex Download

@article{65464904395a42f68054e9de488a3312,
title = "Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function",
abstract = "We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (SI). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p < 0.05). Higher gSAT respiration was associated with higher gynoid fat (p < 0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p < 0.05). In response to training, SI improved and gynoid fat decreased (p < 0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p < 0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.",
author = "Mendham, {Amy E.} and Steen Larsen and Cindy George and Kevin Adams and Jon Hauksson and Tommy Olsson and {Fortuin-de Smidt}, {Melony C.} and {Nono Nankam}, {Pamela A.} and Olah Hakim and Goff, {Louise M.} and Carmen Pheiffer and Goedecke, {Julia H.}",
year = "2020",
month = "12",
day = "1",
doi = "10.1038/s41598-020-60286-x",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function

AU - Mendham, Amy E.

AU - Larsen, Steen

AU - George, Cindy

AU - Adams, Kevin

AU - Hauksson, Jon

AU - Olsson, Tommy

AU - Fortuin-de Smidt, Melony C.

AU - Nono Nankam, Pamela A.

AU - Hakim, Olah

AU - Goff, Louise M.

AU - Pheiffer, Carmen

AU - Goedecke, Julia H.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (SI). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p < 0.05). Higher gSAT respiration was associated with higher gynoid fat (p < 0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p < 0.05). In response to training, SI improved and gynoid fat decreased (p < 0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p < 0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.

AB - We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (SI). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p < 0.05). Higher gSAT respiration was associated with higher gynoid fat (p < 0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p < 0.05). In response to training, SI improved and gynoid fat decreased (p < 0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p < 0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.

UR - http://www.scopus.com/inward/record.url?scp=85081043315&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-60286-x

DO - 10.1038/s41598-020-60286-x

M3 - Article

C2 - 32123205

AN - SCOPUS:85081043315

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3785

ER -

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