Exosomes and Cardiovascular Protection

Sean M. Davidson; Kaloyan Takov; Derek M. Yellon

doi:10.1007/s10557-016-6698-6

Exosomes and Cardiovascular Protection

Sean M. Davidson^*
, Kaloyan Takov
, Derek M. Yellon

^*Corresponding author for this work

Vascular Biology

The Hatter Cardiovascular Institute

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.

Original language	English
Pages (from-to)	77-86
Number of pages	10
Journal	Cardiovascular Drugs and Therapy
Volume	31
Issue number	1
DOIs	https://doi.org/10.1007/s10557-016-6698-6
Publication status	Published - 1 Feb 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardioprotection
Exosomes
Microparticles
Microvesicles
Stem cells

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10.1007/s10557-016-6698-6

Cite this

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title = "Exosomes and Cardiovascular Protection",

abstract = "Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.",

keywords = "Cardioprotection, Exosomes, Microparticles, Microvesicles, Stem cells",

author = "Davidson, \{Sean M.\} and Kaloyan Takov and Yellon, \{Derek M.\}",

note = "Funding Information: This study was funded by a 4 year PhD studentship from the British Heart Foundation, and Biomedical Research Council BRC233/CM/SD/101,320. This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health{\textquoteright}s NIHR Biomedical Research Centres funding scheme. Publisher Copyright: {\textcopyright} 2016, The Author(s).",

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AU - Davidson, Sean M.

AU - Takov, Kaloyan

AU - Yellon, Derek M.

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PY - 2017/2/1

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N2 - Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.

AB - Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.

KW - Cardioprotection

KW - Exosomes

KW - Microparticles

KW - Microvesicles

KW - Stem cells

UR - https://www.scopus.com/pages/publications/84992691614

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DO - 10.1007/s10557-016-6698-6

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ER -

Exosomes and Cardiovascular Protection

Abstract

UN SDGs

Keywords

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