Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

Jose M Anton-Rodriguez; Georgios Krokos; Fotis Kotasidis; Marie-Claude Asselin; Olivia Morris; Peter Julyan; Anthony Archer; Julian C Matthews

doi:10.1088/1361-6560/aaecb6

Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

Jose M Anton-Rodriguez, Georgios Krokos, Fotis Kotasidis, Marie-Claude Asselin, Olivia Morris, Peter Julyan, Anthony Archer, Julian C Matthews

Imaging and Biomedical Engineering

Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, M13 9WL, UK.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data. A double 3D Gaussian function was fitted to the estimated and measured data and used to model the spatially varying PSFs over the scanner field of view (FOV). Differences between the measured and estimated PSFs were quantified using the full-width-at-half-maximum (FWHM) and full-width-at-tenth-maximum (FWTM) in the tangential, radial and axial directions. While estimated PSFs were generally in agreement with the measured PSFs over the entire FOV better agreement was observed (FWHM and FWTM differences of less than 10%) when using one of the two sets of positron range simulations, especially for gallium-68 and for the FWTM. Spatially variant radioisotope specific PSFs can be accurately estimated from fluorine-18 measurements and published positron range data. We have experimentally validated this approach for carbon-11 and gallium-68, and such an approach may be applicable to other radioisotopes such as oxygen-15 for which measurements are not practical.

Original language	English
Pages (from-to)	24NT01
Journal	Physics in Medicine and Biology
Volume	63
Issue number	24
DOIs	https://doi.org/10.1088/1361-6560/aaecb6
Publication status	Published - 7 Dec 2018

Keywords

Carbon Radioisotopes/analysis
Computer Simulation
Electrons
Fluorine Radioisotopes/analysis
Gallium Radioisotopes/analysis
Humans
Image Processing, Computer-Assisted/methods
Monte Carlo Method
Oxygen Radioisotopes/analysis
Phantoms, Imaging
Positron-Emission Tomography/methods

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10.1088/1361-6560/aaecb6

Cite this

Anton-Rodriguez, J. M., Krokos, G., Kotasidis, F., Asselin, M.-C., Morris, O., Julyan, P., Archer, A., & Matthews, J. C. (2018). Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements. Physics in Medicine and Biology, 63(24), 24NT01. https://doi.org/10.1088/1361-6560/aaecb6

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title = "Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements",

abstract = "In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data. A double 3D Gaussian function was fitted to the estimated and measured data and used to model the spatially varying PSFs over the scanner field of view (FOV). Differences between the measured and estimated PSFs were quantified using the full-width-at-half-maximum (FWHM) and full-width-at-tenth-maximum (FWTM) in the tangential, radial and axial directions. While estimated PSFs were generally in agreement with the measured PSFs over the entire FOV better agreement was observed (FWHM and FWTM differences of less than 10%) when using one of the two sets of positron range simulations, especially for gallium-68 and for the FWTM. Spatially variant radioisotope specific PSFs can be accurately estimated from fluorine-18 measurements and published positron range data. We have experimentally validated this approach for carbon-11 and gallium-68, and such an approach may be applicable to other radioisotopes such as oxygen-15 for which measurements are not practical.",

keywords = "Carbon Radioisotopes/analysis, Computer Simulation, Electrons, Fluorine Radioisotopes/analysis, Gallium Radioisotopes/analysis, Humans, Image Processing, Computer-Assisted/methods, Monte Carlo Method, Oxygen Radioisotopes/analysis, Phantoms, Imaging, Positron-Emission Tomography/methods",

author = "Anton-Rodriguez, {Jose M} and Georgios Krokos and Fotis Kotasidis and Marie-Claude Asselin and Olivia Morris and Peter Julyan and Anthony Archer and Matthews, {Julian C}",

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month = dec,

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Anton-Rodriguez, JM, Krokos, G, Kotasidis, F, Asselin, M-C, Morris, O, Julyan, P, Archer, A & Matthews, JC 2018, 'Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements', Physics in Medicine and Biology, vol. 63, no. 24, pp. 24NT01. https://doi.org/10.1088/1361-6560/aaecb6

Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements. / Anton-Rodriguez, Jose M; Krokos, Georgios; Kotasidis, Fotis et al.
In: Physics in Medicine and Biology, Vol. 63, No. 24, 07.12.2018, p. 24NT01.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

AU - Anton-Rodriguez, Jose M

AU - Krokos, Georgios

AU - Kotasidis, Fotis

AU - Asselin, Marie-Claude

AU - Morris, Olivia

AU - Julyan, Peter

AU - Archer, Anthony

AU - Matthews, Julian C

PY - 2018/12/7

Y1 - 2018/12/7

N2 - In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data. A double 3D Gaussian function was fitted to the estimated and measured data and used to model the spatially varying PSFs over the scanner field of view (FOV). Differences between the measured and estimated PSFs were quantified using the full-width-at-half-maximum (FWHM) and full-width-at-tenth-maximum (FWTM) in the tangential, radial and axial directions. While estimated PSFs were generally in agreement with the measured PSFs over the entire FOV better agreement was observed (FWHM and FWTM differences of less than 10%) when using one of the two sets of positron range simulations, especially for gallium-68 and for the FWTM. Spatially variant radioisotope specific PSFs can be accurately estimated from fluorine-18 measurements and published positron range data. We have experimentally validated this approach for carbon-11 and gallium-68, and such an approach may be applicable to other radioisotopes such as oxygen-15 for which measurements are not practical.

AB - In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data. A double 3D Gaussian function was fitted to the estimated and measured data and used to model the spatially varying PSFs over the scanner field of view (FOV). Differences between the measured and estimated PSFs were quantified using the full-width-at-half-maximum (FWHM) and full-width-at-tenth-maximum (FWTM) in the tangential, radial and axial directions. While estimated PSFs were generally in agreement with the measured PSFs over the entire FOV better agreement was observed (FWHM and FWTM differences of less than 10%) when using one of the two sets of positron range simulations, especially for gallium-68 and for the FWTM. Spatially variant radioisotope specific PSFs can be accurately estimated from fluorine-18 measurements and published positron range data. We have experimentally validated this approach for carbon-11 and gallium-68, and such an approach may be applicable to other radioisotopes such as oxygen-15 for which measurements are not practical.

KW - Carbon Radioisotopes/analysis

KW - Computer Simulation

KW - Electrons

KW - Fluorine Radioisotopes/analysis

KW - Gallium Radioisotopes/analysis

KW - Humans

KW - Image Processing, Computer-Assisted/methods

KW - Monte Carlo Method

KW - Oxygen Radioisotopes/analysis

KW - Phantoms, Imaging

KW - Positron-Emission Tomography/methods

U2 - 10.1088/1361-6560/aaecb6

DO - 10.1088/1361-6560/aaecb6

M3 - Article

C2 - 30524089

SN - 0031-9155

VL - 63

SP - 24NT01

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 24

ER -

Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

Abstract

Keywords

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