Exploring causal mechanisms of psychosis risk

Dominic Oliver; Edward Chesney; Alexis E. Cullen; Cathy Davies; Amir Englund; George Gifford; Sarah Kerins; Paris alexandros Lalousis; Yanakan Logeswaran; Kate Merritt; Uzma Zahid; Nicolas A. Crossley; Robert A. Mccutcheon; Philip Mcguire; Paolo Fusar-Poli

doi:10.1016/j.neubiorev.2024.105699

Exploring causal mechanisms of psychosis risk

Dominic Oliver^*, Edward Chesney, Alexis E. Cullen, Cathy Davies, Amir Englund, George Gifford, Sarah Kerins, Paris alexandros Lalousis, Yanakan Logeswaran, Kate Merritt, Uzma Zahid, Nicolas A. Crossley, Robert A. Mccutcheon, Philip Mcguire, Paolo Fusar-Poli

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.

Original language	English
Article number	105699
Journal	Neuroscience and Biobehavioral Reviews
Volume	162
Early online date	13 May 2024
DOIs	https://doi.org/10.1016/j.neubiorev.2024.105699
Publication status	Published - 1 Jul 2024

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Exploring causal mechanisms of_OLIVER_Publishedonline13May2024_GOLD_VoR (CC BY)Final published version, 1.77 MBLicence: CC BY

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Oliver, D., Chesney, E., Cullen, A. E., Davies, C., Englund, A., Gifford, G., Kerins, S., Lalousis, P. A., Logeswaran, Y., Merritt, K., Zahid, U., Crossley, N. A., Mccutcheon, R. A., Mcguire, P., & Fusar-Poli, P. (2024). Exploring causal mechanisms of psychosis risk. Neuroscience and Biobehavioral Reviews, 162, Article 105699. https://doi.org/10.1016/j.neubiorev.2024.105699

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abstract = "Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.",

author = "Dominic Oliver and Edward Chesney and Cullen, {Alexis E.} and Cathy Davies and Amir Englund and George Gifford and Sarah Kerins and Lalousis, {Paris alexandros} and Yanakan Logeswaran and Kate Merritt and Uzma Zahid and Crossley, {Nicolas A.} and Mccutcheon, {Robert A.} and Philip Mcguire and Paolo Fusar-Poli",

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doi = "10.1016/j.neubiorev.2024.105699",

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T1 - Exploring causal mechanisms of psychosis risk

AU - Oliver, Dominic

AU - Chesney, Edward

AU - Cullen, Alexis E.

AU - Davies, Cathy

AU - Englund, Amir

AU - Gifford, George

AU - Kerins, Sarah

AU - Lalousis, Paris alexandros

AU - Logeswaran, Yanakan

AU - Merritt, Kate

AU - Zahid, Uzma

AU - Crossley, Nicolas A.

AU - Mccutcheon, Robert A.

AU - Mcguire, Philip

AU - Fusar-Poli, Paolo

PY - 2024/7/1

Y1 - 2024/7/1

N2 - Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.

AB - Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.

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U2 - 10.1016/j.neubiorev.2024.105699

DO - 10.1016/j.neubiorev.2024.105699

M3 - Review article

SN - 0149-7634

VL - 162

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

M1 - 105699

ER -

Exploring causal mechanisms of psychosis risk

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