Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain

M J Hurley; D C Mash; P Jenner

doi:10.1007/s00702-003-0033-7

Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain

M J Hurley, D C Mash, P Jenner

King's College London

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.

Original language	English
Pages (from-to)	1279 - 1288
Number of pages	10
Journal	Journal of Neural Transmission
Volume	110
Issue number	11
DOIs	https://doi.org/10.1007/s00702-003-0033-7
Publication status	Published - Nov 2003

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title = "Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain",

abstract = "Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.",

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AB - Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.

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Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain

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