Expression of voltage-dependent potassium channels in first trimester human placentae

H. D. Mistry; L. O. Kurlak; G. S. Whitley; J. E. Cartwright; F. Broughton Pipkin; R. M. Tribe

doi:10.1016/j.placenta.2014.02.008

Expression of voltage-dependent potassium channels in first trimester human placentae

H. D. Mistry^*, L. O. Kurlak, G. S. Whitley, J. E. Cartwright, F. Broughton Pipkin, R. M. Tribe

^*Corresponding author for this work

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Potassium channel alpha-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (K(V)7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <= 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of K(V)7 channels in first trimester placentae.

Original language	English
Pages (from-to)	337-340
Number of pages	4
Journal	Placenta
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.placenta.2014.02.008
Publication status	Published - May 2014

Keywords

Potassium channel
Placenta
Early pregnancy
KCNQ
KCNE
K+ CHANNELS
EPITHELIAL-CELLS
VASOCONSTRICTION
DIFFERENTIATION

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10.1016/j.placenta.2014.02.008

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title = "Expression of voltage-dependent potassium channels in first trimester human placentae",

abstract = "Potassium channel alpha-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (K(V)7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <= 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of K(V)7 channels in first trimester placentae.",

keywords = "Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE, K+ CHANNELS, EPITHELIAL-CELLS, VASOCONSTRICTION, DIFFERENTIATION",

author = "Mistry, {H. D.} and Kurlak, {L. O.} and Whitley, {G. S.} and Cartwright, {J. E.} and Pipkin, {F. Broughton} and Tribe, {R. M.}",

year = "2014",

month = may,

doi = "10.1016/j.placenta.2014.02.008",

language = "English",

volume = "35",

pages = "337--340",

journal = "Placenta",

issn = "0143-4004",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Expression of voltage-dependent potassium channels in first trimester human placentae

AU - Mistry, H. D.

AU - Kurlak, L. O.

AU - Whitley, G. S.

AU - Cartwright, J. E.

AU - Pipkin, F. Broughton

AU - Tribe, R. M.

PY - 2014/5

Y1 - 2014/5

N2 - Potassium channel alpha-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (K(V)7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <= 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of K(V)7 channels in first trimester placentae.

AB - Potassium channel alpha-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (K(V)7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <= 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of K(V)7 channels in first trimester placentae.

KW - Potassium channel

KW - Placenta

KW - Early pregnancy

KW - KCNQ

KW - KCNE

KW - K+ CHANNELS

KW - EPITHELIAL-CELLS

KW - VASOCONSTRICTION

KW - DIFFERENTIATION

U2 - 10.1016/j.placenta.2014.02.008

DO - 10.1016/j.placenta.2014.02.008

M3 - Article

SN - 0143-4004

VL - 35

SP - 337

EP - 340

JO - Placenta

JF - Placenta

IS - 5

ER -

Expression of voltage-dependent potassium channels in first trimester human placentae

Abstract

Keywords

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