Extent of piriform cortex resection in children with temporal lobe epilepsy

Rory J. Piper*, Debayan Dasgupta, Maria H. Eriksson, Mathilde Ripart, Almira Moosa, Aswin Chari, Kiran K. Seunarine, Chris A. Clark, John S. Duncan, David W. Carmichael, Martin M. Tisdall, Torsten Baldeweg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: A greater extent of resection of the temporal portion of the piriform cortex (PC) has been shown to be associated with higher likelihood of seizure freedom in adults undergoing anterior temporal lobe resection (ATLR) for drug-resistant temporal lobe epilepsy (TLE). There have been no such studies in children, therefore this study aimed to investigate this association in a pediatric cohort. 

Methods: A retrospective, neuroimaging cohort study of children with TLE who underwent ATLR between 2012 and 2021 was undertaken. The PC, hippocampal and amygdala volumes were measured on the preoperative and postoperative T1-weighted MRI. Using these volumes, the extent of resection per region was compared between the seizure-free and not seizure-free groups. 

Results: In 50 children (median age 9.5 years) there was no significant difference between the extent of resection of the temporal PC in the seizure-free (median = 50%, n = 33/50) versus not seizure-free (median = 40%, n = 17/50) groups (p = 0.26). In a sub-group of 19 with ipsilateral hippocampal atrophy (quantitatively defined by ipsilateral-to-contralateral asymmetry), the median extent of temporal PC resection was greater in children who were seizure-free (53%) versus those not seizure-free (19%) (p = 0.009). 

Interpretation: This is the first study demonstrating that, in children with TLE and hippocampal atrophy, more extensive temporal PC resection is associated with a greater chance of seizure freedom—compatible with an adult series in which 85% of patients had hippocampal sclerosis. In a combined group of children with and without hippocampal atrophy, the extent of PC resection was not associated with seizure outcome, suggesting different epileptogenic networks within this cohort.

Original languageEnglish
Pages (from-to)1613-1622
Number of pages10
JournalAnnals of Clinical and Translational Neurology
Volume10
Issue number9
Early online date20 Jul 2023
DOIs
Publication statusPublished - 15 Sept 2023

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